TBX3

TBX3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H6F
Dynodwyr
Cyfenwau	TBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 3
Dynodwyr allanol	OMIM: 601621 HomoloGene: 4371 GeneCards: TBX3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell Prosesau biolegol • forelimb morphogenesis • cellular senescence • branching involved in mammary gland duct morphogenesis • positive regulation of stem cell proliferation • atrioventricular bundle cell differentiation • negative regulation of epithelial cell differentiation • female genitalia development • transcription, DNA-templated • male genitalia development • multicellular organism development • anterior/posterior axis specification, embryo • outflow tract morphogenesis • skeletal system development • ventricular septum morphogenesis • embryonic forelimb morphogenesis • cardiac muscle cell fate commitment • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • heart morphogenesis • regulation of cell population proliferation • heart looping • negative regulation of myoblast differentiation • specification of animal organ position • stem cell population maintenance • luteinizing hormone secretion • follicle-stimulating hormone secretion • blood vessel development • positive regulation of cell population proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • roof of mouth development • mammary placode formation • in utero embryonic development • mesoderm morphogenesis • GO:0009373 regulation of transcription, DNA-templated • limb morphogenesis • sinoatrial node cell development • positive regulation of cell cycle • cardiac muscle cell differentiation • limbic system development • embryonic hindlimb morphogenesis • animal organ morphogenesis • embryonic heart tube development • embryonic digit morphogenesis • mammary gland development • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6926	n/a
Ensembl	ENSG00000135111	n/a
UniProt	O15119	n/a
RefSeq (mRNA)	NM_016569 NM_005996	n/a
RefSeq (protein)	NP_005987 NP_057653	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TBX3 yw TBX3 a elwir hefyd yn T-box 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TBX3.

• UMS
• XHL
• TBX3-ISO

Llyfryddiaeth

• "Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population. ". PLoS One. 2016. PMID 27195777.
• "Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma. ". Asian Pac J Cancer Prev. 2015. PMID 25743805.
• "Novel TBX3 mutation in a family of Cypriot ancestry with ulnar-mammary syndrome. ". Clin Dysmorphol. 2017. PMID 28145909.
• "Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion. ". Virchows Arch. 2016. PMID 27553355.
• "The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer.". BMC Cancer. 2016. PMID 27553211.