TBX2 Dynodwyr Cyfenwau TBX2 Dynodwyr allanol OMIM: 600747 HomoloGene: 38123 GeneCards: TBX2 Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • transcription regulator complex • cnewyllyn cell Prosesau biolegol • Notch signaling pathway • roof of mouth development • atrioventricular canal development • pharynx development • GO:0009373 regulation of transcription, DNA-templated • regulation of heart contraction • cardiac muscle tissue development • negative regulation of heart looping • mammary placode formation • embryonic digit morphogenesis • heart morphogenesis • outflow tract morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • aorta morphogenesis • transcription, DNA-templated • embryonic heart tube development • outflow tract septum morphogenesis • endocardial cushion morphogenesis • multicellular organism development • heart looping • muscle cell fate determination • cellular senescence • developmental growth involved in morphogenesis • positive regulation of cardiac muscle cell proliferation • embryonic camera-type eye morphogenesis • positive regulation of cell population proliferation • negative regulation of cardiac chamber formation • GO:0045996 negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn TBX2 yw TBX2 a elwir hefyd yn T-box 2 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.2.[2]
"Increased expression of TBX2 is a novel independent prognostic biomarker of a worse outcome in colorectal cancer patients after curative surgery and a potential therapeutic target. ". Med Oncol . 2013. PMID 23959449 . "TBX2 gene duplication associated with complex heart defect and skeletal malformations. ". Am J Med Genet A . 2010. PMID 20635360 . "High TBX2 expression predicts poor prognosis in non-small cell lung cancer. ". Neoplasma . 2014. PMID 25027744 . "TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells. ". Int J Cancer . 2014. PMID 24470334 . "A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance. ". Cell Death Dis . 2013. PMID 24113180 . 
