TARDBP

TARDBP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WF0, 2CQG, 4BS2, 4IUF, 4Y0F, 2N4P, 2N2C, 4Y00, 2N4G, 2N4H, 2N3X
Dynodwyr
Cyfenwau	TARDBP, ALS10, TDP-43, TAR DNA binding protein
Dynodwyr allanol	OMIM: 605078 HomoloGene: 7221 GeneCards: TARDBP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • mRNA 3'-UTR binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • identical protein binding • RNA binding • nucleic acid binding • double-stranded DNA binding • single-stranded RNA binding • sequence-specific double-stranded DNA binding Cydrannau o'r gell • cytoplasm • nuclear speck • nucleoplasm • interchromatin granule • perichromatin fibrils • cnewyllyn cell • ribonucleoprotein complex • cytoplasmic stress granule Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • mRNA processing • negative regulation of gene expression • response to endoplasmic reticulum stress • transcription, DNA-templated • regulation of cell cycle • negative regulation by host of viral transcription • RNA splicing • nuclear inner membrane organization • 3'-UTR-mediated mRNA stabilization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of insulin secretion • transcription by RNA polymerase II • regulation of apoptotic process • positive regulation of protein import into nucleus • regulation of protein stability • regulation of circadian rhythm • proses rythmig Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23435	n/a
Ensembl	ENSG00000120948	n/a
UniProt	Q13148	n/a
RefSeq (mRNA)	NM_007375	n/a
RefSeq (protein)	NP_031401 NP_031401.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TARDBP yw TARDBP a elwir hefyd yn TAR DNA binding protein, isoform CRA_b a TAR DNA binding protein, isoform CRA_d (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TARDBP.

• ALS10
• TDP-43

Llyfryddiaeth

• "Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy. ". J Neuropathol Exp Neurol. 2017. PMID 28789478.
• "Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects. ". PLoS One. 2017. PMID 28686708.
• "Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. ". Lancet Neurol. 2017. PMID 28919059.
• "Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease. ". J Neuropathol Exp Neurol. 2017. PMID 28859337.
• "Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.". Biophys J. 2017. PMID 28793209.