TARBP2

TARBP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CPN, 3ADL, 3LLH, 4WYQ
Dynodwyr
Cyfenwau	TARBP2, LOQS, TRBP, TRBP1, TRBP2, RISC loading complex RNA binding subunit, TARBP2 subunit of RISC loading complex
Dynodwyr allanol	OMIM: 605053 HomoloGene: 7562 GeneCards: TARBP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • GO:0001948, GO:0016582 protein binding • siRNA binding • RNA binding • enzyme binding • pre-mRNA binding • double-stranded RNA binding • identical protein binding • protein homodimerization activity • pre-miRNA binding • miRNA binding Cydrannau o'r gell • cytoplasm • cytosol • perinuclear region of cytoplasm • cnewyllyn cell • nucleoplasm • nuclear body • RISC-loading complex • RISC complex Prosesau biolegol • regulation of viral transcription • negative regulation of protein kinase activity • multicellular organism growth • positive regulation of translation • single fertilization • negative regulation of defense response to virus by host • spermatid development • positive regulation of viral genome replication • regulation of translation • production of miRNAs involved in gene silencing by miRNA • GO:0061715 miRNA metabolic process • gene silencing • GO:0070919 production of siRNA involved in RNA interference • pre-miRNA processing • regulation of production of miRNAs involved in gene silencing by miRNA • skeletal muscle tissue regeneration • positive regulation of muscle cell differentiation • neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6895	n/a
Ensembl	ENSG00000139546	n/a
UniProt	Q15633	n/a
RefSeq (mRNA)	NM_004178 NM_134323 NM_134324	n/a
RefSeq (protein)	NP_004169 NP_599150 NP_599151	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TARBP2 yw TARBP2 a elwir hefyd yn TARBP2, RISC loading complex RNA binding subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TARBP2.

• LOQS
• TRBP
• TRBP1
• TRBP2

Llyfryddiaeth

• "SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. ". Nat Commun. 2015. PMID 26582366.
• "The role of TARBP2 in the development and progression of cancers. ". Tumour Biol. 2016. PMID 26486325.
• "The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. ". Biochem Biophys Res Commun. 2016. PMID 27743889.
• "shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathway. ". Mol Med Rep. 2016. PMID 27599909.
• "Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA.". Biophys J. 2016. PMID 27332119.