TAP1

TAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JJ7
Dynodwyr
Cyfenwau	TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member
Dynodwyr allanol	OMIM: 170260 HomoloGene: 495 GeneCards: TAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • MHC protein binding • nucleotide binding • protein homodimerization activity • ABC-type peptide transporter activity • TAP2 binding • MHC class Ib protein binding • ATPase activity • GO:0001948, GO:0016582 protein binding • MHC class I protein binding • TAP1 binding • ATP binding • peptide antigen binding • ADP binding • ATPase-coupled transmembrane transporter activity • ABC-type peptide antigen transporter activity • peptide transmembrane transporter activity Cydrannau o'r gell • integral component of membrane • endoplasmic reticulum membrane • bilen • TAP complex • integral component of endoplasmic reticulum membrane • mitocondria • Reticwlwm endoplasmig • microtubule organizing center • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • MHC class I peptide loading complex Prosesau biolegol • defense response • adaptive immune response • immune system process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class I • protein transport • peptide transport • GO:0022415 viral process • cytosol to endoplasmic reticulum transport • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • transmembrane transport • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6890	n/a
Ensembl	ENSG00000226173 ENSG00000168394 ENSG00000224212 ENSG00000230705 ENSG00000206297 ENSG00000227816 ENSG00000224748 ENSG00000232367	n/a
UniProt	Q03518	n/a
RefSeq (mRNA)	NM_001292022 NM_000593	n/a
RefSeq (protein)	NP_000584 NP_001278951	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAP1 yw TAP1 a elwir hefyd yn Transporter 1, ATP binding cassette subfamily B member (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAP1.

• APT1
• PSF1
• ABC17
• ABCB2
• PSF-1
• RING4
• TAP1N
• D6S114E
• TAP1*0102N

Llyfryddiaeth

• "Evaluation of PSF1 as a prognostic biomarker for prostate cancer. ". Prostate Cancer Prostatic Dis. 2015. PMID 25403418.
• "Knockdown of PSF1 expression inhibits cell proliferation in lung cancer cells in vitro. ". Tumour Biol. 2015. PMID 25398693.
• "Association between TAP1 gene polymorphisms and alopecia areata in a Korean population. ". Genet Mol Res. 2015. PMID 26782532.
• "Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma. ". PLoS One. 2016. PMID 26735690.
• "Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.". Nat Commun. 2015. PMID 25656091.