TANK

TANK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KZZ, 1L0A
Dynodwyr
Cyfenwau	TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
Dynodwyr allanol	OMIM: 603893 HomoloGene: 3081 GeneCards: TANK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • metal ion binding • deubiquitinase activator activity • thiol-dependent deubiquitinase Cydrannau o'r gell • cytoplasm • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • TRIF-dependent toll-like receptor signaling pathway • GO:0072468 signal transduction • positive regulation of ubiquitin-specific protease activity • positive regulation of protein deubiquitination • cellular response to tumor necrosis factor • negative regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to interleukin-1 • proteolysis • cellular response to ionizing radiation • cellular response to DNA damage stimulus • I-kappaB kinase/NF-kappaB signaling • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10010	n/a
Ensembl	ENSG00000136560	n/a
UniProt	Q92844 Q6NW12	n/a
RefSeq (mRNA)	NM_001199135 NM_004180 NM_133484	n/a
RefSeq (protein)	NP_001186064 NP_004171 NP_597841 NP_001186064.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TANK yw TANK a elwir hefyd yn TANK protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TANK.

• ITRAF
• TRAF2
• I-TRAF

Llyfryddiaeth

• "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women. ". Bone. 2003. PMID 14499357.
• "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. ". Proc Natl Acad Sci U S A. 1996. PMID 8855313.
• "TRAF family member-associated NF-KB activator (TANK) gene polymorphism in chronic periodontitis and peri-implantitis patients. ". J Long Term Eff Med Implants. 2012. PMID 23428248.
• "Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population. ". Viral Immunol. 2012. PMID 22225470.
• "TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation.". Biochem J. 2006. PMID 16336209.