TAF1 Dynodwyr Cyfenwau TAF1 Dynodwyr allanol OMIM: 313650 HomoloGene: 37942 GeneCards: TAF1 Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • DNA binding • GO:0001105 transcription coactivator activity • p53 binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • lysine-acetylated histone binding • TBP-class protein binding • acyltransferase activity • ATP binding • protein serine/threonine kinase activity • histone acetyltransferase activity • kinase activity • protein heterodimerization activity • H3K27me3 modified histone binding • ubiquitin conjugating enzyme activity • acetyl-CoA binding • sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II-specific DNA-binding transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000983 RNA polymerase II general transcription initiation factor activity Cydrannau o'r gell • nucleoplasm • MLL1 complex • cnewyllyn cell • nucleolus • transcription regulator complex • transcription factor TFIID complex Prosesau biolegol • phosphorylation • RNA polymerase II preinitiation complex assembly • transcription by RNA polymerase II • positive regulation of transcription initiation from RNA polymerase II promoter • transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • DNA-templated transcription, initiation • protein autophosphorylation • cell cycle • transcription initiation from RNA polymerase II promoter • peptidyl-threonine phosphorylation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of signal transduction by p53 class mediator • GO:0022415 viral process • histone acetylation • protein polyubiquitination • protein phosphorylation • cellular response to DNA damage stimulus • negative regulation of gene expression • midbrain development • positive regulation of protein binding • cellular response to UV • transcription factor catabolic process • protein stabilization • regulation of transcription initiation from RNA polymerase II promoter • cellular response to ATP • regulation of cell cycle G1/S phase transition • negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding • negative regulation of protein autoubiquitination • negative regulation of ubiquitin-dependent protein catabolic process • positive regulation of androgen receptor activity • positive regulation of transcription by RNA polymerase I • GO:0009373 regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • negative regulation of DNA-binding transcription factor activity • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn TAF1 yw TAF1 a elwir hefyd yn TATA-box binding protein associated factor 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAF1.
OF
XDP
BA2R
CCG1
CCGS
DYT3
KAT4
P250
NSCL2
TAF2A
MRXS33
N-TAF1
TAFII250
DYT3/TAF1
TAFII-250
TAF(II)250
. 1993. PMID 20301662 . "The monogenic primary dystonias. ". Brain . 2009. PMID 19578124 . "Evidence of TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism. ". Cell Mol Life Sci . 2016. PMID 26879577 . "Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. ". Dis Model Mech . 2016. PMID 26769797 . "TAFI gene polymorphisms in patients with cerebral venous thrombosis. ". Acta Neurol Belg . 2013. PMID 23264082 . 
