TAB2

TAB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DAE, 2WWZ, 2WX0, 2WX1
Dynodwyr
Cyfenwau	TAB2, CHTD2, MAP3K7IP2, TAB-2, TGF-beta activated kinase 1/MAP3K7 binding protein 2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Dynodwyr allanol	OMIM: 605101 HomoloGene: 9019 GeneCards: TAB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • K63-linked polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • endosome membrane • cytoplasm • bilen • Cellbilen • cytosol • nucleoplasm Prosesau biolegol • JNK cascade • positive regulation of NF-kappaB transcription factor activity • positive regulation of protein kinase activity • Fc-epsilon receptor signaling pathway • heart development • nucleotide-binding oligomerization domain containing signaling pathway • MyD88-dependent toll-like receptor signaling pathway • stimulatory C-type lectin receptor signaling pathway • I-kappaB kinase/NF-kappaB signaling • negative regulation of autophagy • positive regulation of I-kappaB kinase/NF-kappaB signaling • T cell receptor signaling pathway • interleukin-1-mediated signaling pathway • response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23118	n/a
Ensembl	ENSG00000055208	n/a
UniProt	Q9NYJ8	n/a
RefSeq (mRNA)	NM_001292034 NM_001292035 NM_015093 NM_145342 NM_001369506	n/a
RefSeq (protein)	NP_001278963 NP_001278964 NP_055908 NP_001356435	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAB2 yw TAB2 a elwir hefyd yn TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 a TGF-beta activated kinase 1/MAP3K7 binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAB2.

• CHTD2
• TAB-2
• MAP3K7IP2

Llyfryddiaeth

• "HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. ". Biochem Biophys Res Commun. 2008. PMID 17986383.
• "A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. ". Diabetes. 2004. PMID 15220215.
• "Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome. ". Congenit Heart Dis. 2016. PMID 27452334.
• "Familial TAB2 microdeletion and congenital heart defects including unusual valve dysplasia and tetralogy of fallot. ". Am J Med Genet A. 2015. PMID 26139517.
• "A de novo 0.63 Mb 6q25.1 deletion associated with growth failure, congenital heart defect, underdeveloped cerebellar vermis, abnormal cutaneous elasticity and joint laxity.". Am J Med Genet A. 2015. PMID 25940952.