SYT1

SYT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K45, 2K4A, 2K8M, 2KI6, 2LHA, 2N1T, 2R83, 3F00, 3F01, 3F04, 3F05, 4ISQ, 4V11
Dynodwyr
Cyfenwau	SYT1, P65, SVP65, SYT, synaptotagmin 1, BAGOS
Dynodwyr allanol	OMIM: 185605 HomoloGene: 4122 GeneCards: SYT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein C-terminus binding • metal ion binding • phosphatidylinositol-4,5-bisphosphate binding • calcium ion binding • clathrin binding • identical protein binding • calcium-dependent protein binding • phospholipid binding • SNARE binding • calmodulin binding • 1-phosphatidylinositol binding • phosphatidylserine binding • low-density lipoprotein particle receptor binding • syntaxin binding • GO:0001948, GO:0016582 protein binding • syntaxin-1 binding • calcium-dependent phospholipid binding • syntaxin-3 binding • protein heterodimerization activity • calcium ion sensor activity Cydrannau o'r gell • terminal bouton • SNARE complex • clathrin-sculpted glutamate transport vesicle membrane • intracellular organelle • cytoplasm • transport vesicle membrane • synapse • integral component of membrane • Golgi apparatus • cell junction • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • presynaptic membrane • dense core granule • clathrin-sculpted monoamine transport vesicle membrane • neuron projection • chromaffin granule membrane • bilen • excitatory synapse • synaptic vesicle • secretory granule • clathrin-sculpted acetylcholine transport vesicle membrane • GO:0016023 cytoplasmic vesicle • synaptic vesicle membrane • Cellbilen • integral component of synaptic vesicle membrane • axon • clathrin-coated vesicle membrane • neuron projection terminus • exocytic vesicle • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse Prosesau biolegol • detection of calcium ion • positive regulation of vesicle fusion • chemical synaptic transmission • synaptic vesicle exocytosis • positive regulation of calcium ion-dependent exocytosis • response to calcium ion • regulation of regulated secretory pathway • brain development • glutamate secretion • positive regulation of dendrite extension • positive regulation of synaptic transmission • regulation of synaptic transmission, glutamatergic • regulation of exocytosis • synaptic vesicle endocytosis • vesicle docking • cell differentiation • fast, calcium ion-dependent exocytosis of neurotransmitter • GO:0010554 neurotransmitter secretion • cellular response to calcium ion • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • regulation of dopamine secretion • protein homooligomerization • protein heterooligomerization • membrane organization • vesicle-mediated transport • calcium-ion regulated exocytosis • calcium-dependent activation of synaptic vesicle fusion • spontaneous neurotransmitter secretion • synchronous neurotransmitter secretion • regulation of synaptic vesicle exocytosis • positive regulation of calcium ion-dependent exocytosis of neurotransmitter Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6857	n/a
Ensembl	ENSG00000067715	n/a
UniProt	P21579	n/a
RefSeq (mRNA)	NM_001135805 NM_001135806 NM_001291901 NM_005639	n/a
RefSeq (protein)	NP_001129277 NP_001129278 NP_001278830 NP_005630	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SYT1 yw SYT1 a elwir hefyd yn Synaptotagmin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SYT1.

• P65
• SYT
• SVP65

Llyfryddiaeth

• "Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering. ". EMBO J. 2015. PMID 26202220.
• "Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling. ". J Clin Invest. 2015. PMID 25705886.
• "The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease. ". Alzheimers Res Ther. 2016. PMID 27716408.
• "The prognostic impact of SYT-SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials. ". Pediatr Blood Cancer. 2017. PMID 27621063.
• "Detection of SYT-SSX mutant transcripts in formalin-fixed paraffin-embedded sarcoma tissues using one-step reverse transcriptase real-time PCR.". Malays J Pathol. 2016. PMID 27126659.