SYNCRIP

SYNCRIP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DGU, 2MXT, 2NBB
Dynodwyr
Cyfenwau	SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q, synaptotagmin binding cytoplasmic RNA interacting protein
Dynodwyr allanol	OMIM: 616686 HomoloGene: 4648 GeneCards: SYNCRIP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • poly(A) binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA binding • mRNA binding • mRNA 5'-UTR binding Cydrannau o'r gell • CRD-mediated mRNA stability complex • cytoplasm • catalytic step 2 spliceosome • histone pre-mRNA 3'end processing complex • intracellular membrane-bounded organelle • nucleoplasm • Reticwlwm endoplasmig • GAIT complex • spliceosomal complex • cnewyllyn cell • bilen • ribonucleoprotein complex Prosesau biolegol • CRD-mediated mRNA stabilization • mRNA splicing, via spliceosome • GO:0033168, GO:0036404, GO:1902360 RNA processing • negative regulation of translation • mRNA processing • osteoblast differentiation • RNA splicing • cellular response to interferon-gamma • GO:0022415 viral process • regulation of translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10492	n/a
Ensembl	ENSG00000135316	n/a
UniProt	O60506	n/a
RefSeq (mRNA)	NM_001159673 NM_001159674 NM_001159675 NM_001159676 NM_001159677 NM_001253771 NM_006372	n/a
RefSeq (protein)	NP_001153145 NP_001153146 NP_001153147 NP_001153148 NP_001153149 NP_001240700 NP_006363	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SYNCRIP yw SYNCRIP a elwir hefyd yn Synaptotagmin binding cytoplasmic RNA interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SYNCRIP.

• PP68
• NSAP1
• GRYRBP
• HNRNPQ
• HNRPQ1
• GRY-RBP
• hnRNP-Q

Llyfryddiaeth

• "The GAIT system: a gatekeeper of inflammatory gene expression. ". Trends Biochem Sci. 2009. PMID 19535251.
• "SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication. ". Virology. 2009. PMID 19232660.
• "The acidic domain is a unique structural feature of the splicing factor SYNCRIP. ". Protein Sci. 2016. PMID 27081926.
• "Identification of proteins specifically interacting with YB-1 mRNA 3' UTR and the effect of hnRNP Q on YB-1 mRNA translation. ". Biochemistry (Mosc). 2013. PMID 23980891.
• "Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1.". Nucleic Acids Res. 2011. PMID 21715376.