SYK

SYK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1A81, 1CSY, 1CSZ, 1XBA, 1XBB, 1XBC, 3BUW, 3EMG, 3FQE, 3FQH, 3FQS, 3SRV, 3TUB, 3TUC, 3TUD, 3VF8, 3VF9, 4DFL, 4DFN, 4F4P, 4FL1, 4FL2, 4FL3, 4FYN, 4FYO, 4FZ6, 4FZ7, 4GFG, 4I0R, 4I0S, 4I0T, 4PUZ, 4PV0, 4PX6, 4RX7, 4RX8, 4RX9, 5CXH, 5CXZ, 5CY3, 4XG6, 4XG2, 4XG3, 4XG8, 4XG7, 4YJR, 4YJP, 5C27, 4RSS, 4XG4, 5C26, 4YJV, 4YJO, 4WNM, 4YJT, 4YJU, 4YJS, 4XG9, 5GHV
Dynodwyr
Cyfenwau	SYK, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase, IMD82
Dynodwyr allanol	OMIM: 600085 HomoloGene: 2390 GeneCards: SYK
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• kinase activity; • ATP binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • protein serine/threonine kinase activity; • transferase activity; • integrin binding; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • protein kinase binding; • nucleotide binding; • phosphatase binding; • Toll-like receptor binding; • phosphotyrosine residue binding; • SH2 domain binding; • interleukin-15 receptor binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • extrinsic component of cytoplasmic side of plasma membrane; • cnewyllyn cell; • early phagosome; • B cell receptor complex; • Cellbilen; • T cell receptor complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• leukocyte cell-cell adhesion; • adaptive immune response; • positive regulation of receptor internalization; • neutrophil activation involved in immune response; • platelet activation; • Fc-epsilon receptor signaling pathway; • protein phosphorylation; • cell surface receptor signaling pathway; • regulation of DNA-binding transcription factor activity; • serotonin secretion; • angiogenesis; • animal organ morphogenesis; • positive regulation of cell adhesion mediated by integrin; • cell population proliferation; • regulation of platelet aggregation; • B cell receptor signaling pathway; • positive regulation of calcium-mediated signaling; • blood vessel morphogenesis; • Fc-gamma receptor signaling pathway involved in phagocytosis; • transmembrane receptor protein tyrosine kinase signaling pathway; • regulation of tumor necrosis factor-mediated signaling pathway; • serotonin secretion by platelet; • cellular response to low-density lipoprotein particle stimulus; • stimulatory C-type lectin receptor signaling pathway; • lymph vessel development; • neutrophil chemotaxis; • macrophage activation involved in immune response; • defense response to bacterium; • positive regulation of alpha-beta T cell proliferation; • regulation of ERK1 and ERK2 cascade; • positive regulation of peptidyl-tyrosine phosphorylation; • protein autophosphorylation; • leukotriene biosynthetic process; • GO:0022415 viral process; • positive regulation of alpha-beta T cell differentiation; • cellular response to molecule of fungal origin; • regulation of neutrophil degranulation; • phosphorylation; • immune system process; • positive regulation of B cell differentiation; • beta selection; • leukocyte activation involved in immune response; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • regulation of superoxide anion generation; • enzyme linked receptor protein signaling pathway; • GO:0007243 intracellular signal transduction; • receptor internalization; • positive regulation of bone resorption; • positive regulation of mast cell degranulation; • regulation of arachidonic acid secretion; • GO:0035404 peptidyl-serine phosphorylation; • peptidyl-tyrosine phosphorylation; • regulation of phagocytosis; • regulation of platelet activation; • positive regulation of gamma-delta T cell differentiation; • positive regulation of type I interferon production; • inflammatory response; • innate immune response; • collagen-activated tyrosine kinase receptor signaling pathway; • positive regulation of peptidyl-tyrosine autophosphorylation; • protein import into nucleus; • positive regulation of interleukin-4 production; • interleukin-2-mediated signaling pathway; • interleukin-3-mediated signaling pathway; • positive regulation of cold-induced thermogenesis; • positive regulation of protein-containing complex assembly; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	6850
	n/a
	ENSG00000165025
	n/a
	P43405
	n/a
	NM_001135052; NM_001174167; NM_001174168; NM_003177
	n/a
	NP_001128524; NP_001167638; NP_001167639; NP_003168
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SYK yw SYK a elwir hefyd yn Spleen associated tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SYK.

p72-Syk

Llyfryddiaeth

"High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients. ". PLoS One. 2017. PMID 28957395.
"High SYK Expression Drives Constitutive Activation of CD21low B Cells. ". J Immunol. 2017. PMID 28468967.
"OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL. ". Anal Biochem. 2016. PMID 27510553.
"Syk expression in non-small-cell lung cancer and its relation with angiogenesis. ". J Cancer Res Ther. 2016. PMID 27461628.
"Novel SYK gene variations and changes in binding sites of miRs in breast cancer patients.". Cancer Biomark. 2016. PMID 26889814.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SYK - Cronfa NCBI

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[2]