SUPT5H

SUPT5H
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DO3, 2E6Z, 2E70, 3H7H, 4L1U
Dynodwyr
Cyfenwau	SUPT5H, SPT5, SPT5H, Tat-CT1, SPT5 homolog, DSIF elongation factor subunit
Dynodwyr allanol	OMIM: 602102 HomoloGene: 2384 GeneCards: SUPT5H
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • chromatin binding • RNA binding • DNA binding • mRNA binding Cydrannau o'r gell • nucleoplasm • DSIF complex • cnewyllyn cell Prosesau biolegol • chromatin remodeling • negative regulation of mRNA polyadenylation • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription elongation from RNA polymerase II promoter • regulation of DNA-templated transcription, elongation • GO:1901227 negative regulation of transcription by RNA polymerase II • 7-methylguanosine mRNA capping • transcription by RNA polymerase II • response to organic substance • transcription, DNA-templated • negative regulation of DNA-templated transcription, elongation • positive regulation of DNA-templated transcription, elongation • positive regulation of macroautophagy • DNA-templated transcription, elongation • single stranded viral RNA replication via double stranded DNA intermediate • positive regulation of viral transcription • cell cycle • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6829	n/a
Ensembl	ENSG00000196235	n/a
UniProt	O00267	n/a
RefSeq (mRNA)	NM_001111020 NM_001130824 NM_001130825 NM_003169 NM_001319990 NM_001319991	n/a
RefSeq (protein)	NP_001104490 NP_001124296 NP_001124297 NP_001306919 NP_001306920 NP_003160	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SUPT5H yw SUPT5H a elwir hefyd yn SPT5 homolog, DSIF elongation factor subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SUPT5H.

• SPT5
• SPT5H
• Tat-CT1

Llyfryddiaeth

• "Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. ". Retrovirology. 2004. PMID 15620346.
• "Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis. ". FEBS Lett. 1997. PMID 9199507.
• "Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. ". Nat Struct Mol Biol. 2017. PMID 28892040.
• "DSIF restricts NF-κB signaling by coordinating elongation with mRNA processing of negative feedback genes. ". Cell Rep. 2012. PMID 23041311.
• "P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.". Mol Cell. 2006. PMID 16427012.