STX1A

STX1A
Dynodwyr
Cyfenwau	STX1A, HPC-1, P35-1, STX1, SYN1A, syntaxin 1A
Dynodwyr allanol	OMIM: 186590 HomoloGene: 37941 GeneCards: STX1A
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium channel inhibitor activity; • transmembrane transporter binding; • protein N-terminus binding; • SNAP receptor activity; • kinase binding; • chloride channel inhibitor activity; • protein heterodimerization activity; • SNARE binding; • GO:0001948, GO:0016582 protein binding; • myosin binding; • protein domain specific binding; • protein-macromolecule adaptor activity; • myosin head/neck binding; • ATP-dependent protein binding; • calcium-dependent protein binding;
Cydrannau o'r gell	• integral component of membrane; • cytosol; • bilen; • synaptic vesicle; • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; • voltage-gated potassium channel complex; • Cellbilen; • synapse; • synaptic vesicle membrane; • secretory granule; • extracellular region; • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; • cell junction; • SNARE complex; • intracellular organelle; • neuron projection; • synaptobrevin 2-SNAP-25-syntaxin-1a complex; • actomyosin; • GO:0016023 cytoplasmic vesicle; • presynaptic membrane; • GO:0097483, GO:0097481 postsynaptic density; • presynaptic active zone membrane; • nuclear membrane; • integral component of plasma membrane; • axon; • GO:0009327 protein-containing complex; • acrosomal vesicle; • integral component of synaptic vesicle membrane; • glutamatergic synapse; • integral component of presynaptic membrane; • endomembrane system; • intracellular anatomical structure;
Prosesau biolegol	• exocytosis; • positive regulation of norepinephrine secretion; • synaptic vesicle docking; • secretion by cell; • regulation of insulin secretion; • positive regulation of catecholamine secretion; • positive regulation of neurotransmitter secretion; • positive regulation of calcium ion-dependent exocytosis; • regulation of exocytosis; • response to gravity; • vesicle docking; • positive regulation of excitatory postsynaptic potential; • positive regulation of exocytosis; • intracellular protein transport; • neurotransmitter transport; • vesicle-mediated transport; • calcium-ion regulated exocytosis; • regulation of synaptic vesicle priming; • protein localization to membrane; • modulation of excitatory postsynaptic potential; • synaptic vesicle fusion to presynaptic active zone membrane; • SNARE complex assembly; • cytokine-mediated signaling pathway; • synaptic vesicle exocytosis; • vesicle fusion; • GO:0010554 neurotransmitter secretion; • glutamate secretion; • protein sumoylation; • insulin secretion; • regulated exocytosis; • hormone secretion; • synaptic vesicle endocytosis; • membrane fusion;
	Sources:Amigo / QuickGO
Orthologau
	6804
	n/a
	ENSG00000106089
	n/a
	Q16623; Q75ME0
	n/a
	NM_001165903; NM_004603
	n/a
	NP_001159375; NP_004594; NP_004594.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STX1A yw STX1A a elwir hefyd yn Putative uncharacterized protein STX1A a Syntaxin 1a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q11.23.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STX1A.

STX1
HPC-1
P35-1
SYN1A

Llyfryddiaeth[golygu | golygu cod]

"Association analysis of STX1A gene variants in common forms of migraine. ". Cephalalgia. 2012. PMID 22250207.
"α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin. ". PLoS One. 2011. PMID 21789195.
"Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth. ". PLoS One. 2015. PMID 25803850.
"Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. ". Proc Natl Acad Sci U S A. 2013. PMID 24218570.
"Clinical and molecular characterization of the potential CF disease modifier syntaxin 1A.". Eur J Hum Genet. 2013. PMID 23572023.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] STX1A - Cronfa NCBI

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[2]