STUB1

STUB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4KBQ
Dynodwyr
Cyfenwau	STUB1, CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, STIP1 homology and U-box containing protein 1, SCA48
Dynodwyr allanol	OMIM: 607207 HomoloGene: 4281 GeneCards: STUB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • Hsp90 protein binding • protein-macromolecule adaptor activity • protein homodimerization activity • misfolded protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0050372 ubiquitin-protein transferase activity • ubiquitin-ubiquitin ligase activity • kinase binding • GO:0001948, GO:0016582 protein binding • enzyme binding • TPR domain binding • G protein-coupled receptor binding • ubiquitin protein ligase binding • transferase activity • Hsp70 protein binding • SMAD binding • heat shock protein binding • tau protein binding • chaperone binding Cydrannau o'r gell • cytoplasm • ubiquitin ligase complex • nucleoplasm • Z disc • Reticwlwm endoplasmig • nuclear inclusion body • extracellular exosome • ubiquitin conjugating enzyme complex • cnewyllyn cell • cytosol • chaperone complex Prosesau biolegol • positive regulation of chaperone-mediated protein complex assembly • regulation of protein stability • ubiquitin-dependent protein catabolic process • regulation of glucocorticoid metabolic process • protein K63-linked ubiquitination • protein maturation • protein polyubiquitination • protein quality control for misfolded or incompletely synthesized proteins • negative regulation of protein binding • ubiquitin-dependent SMAD protein catabolic process • cellular response to DNA damage stimulus • endoplasmic reticulum unfolded protein response • positive regulation of ubiquitin-protein transferase activity • protein ubiquitination • positive regulation of protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0100026 DNA repair • proteasome-mediated ubiquitin-dependent protein catabolic process • protein autoubiquitination • cellular response to misfolded protein • ERBB2 signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • ubiquitin-dependent ERAD pathway • response to ischemia • cellular response to heat • chaperone-mediated autophagy • cellular response to hypoxia Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10273	n/a
Ensembl	ENSG00000103266	n/a
UniProt	Q9UNE7	n/a
RefSeq (mRNA)	NM_005861 NM_001293197	n/a
RefSeq (protein)	NP_001280126 NP_005852	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STUB1 yw STUB1 a elwir hefyd yn STIP1 homology and U-box containing protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STUB1.

• CHIP
• UBOX1
• SCAR16
• HSPABP2
• NY-CO-7
• SDCCAG7

Llyfryddiaeth

• "Regulation of autophagic flux by CHIP. ". Neurosci Bull. 2015. PMID 26219223.
• "Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma. ". Asian Pac J Cancer Prev. 2015. PMID 25987026.
• "STUB1/CHIP mutations cause Gordon Holmes syndrome as part of a widespread multisystemic neurodegeneration: evidence from four novel mutations. ". Orphanet J Rare Dis. 2017. PMID 28193273.
• "Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer. ". Cancer Med. 2016. PMID 27334118.
• "CHIP Knockdown Reduced Heat Shock Response and Protein Quality Control Capacity in Lens Epithelial Cells.". Curr Mol Med. 2015. PMID 26321754.