STRADA

STRADA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UPK, 2WTK, 3GNI
Dynodwyr
Cyfenwau	STRADA, LYK5, NY-BR-96, PMSE, STRAD, Stlk, STE20-related kinase adaptor alpha, STRAD alpha, STE20 related adaptor alpha
Dynodwyr allanol	OMIM: 608626 HomoloGene: 12448 GeneCards: STRADA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein serine/threonine kinase activator activity • protein kinase activator activity • protein kinase activity • ATP binding • nucleotide binding • kinase binding • protein serine/threonine kinase activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • protein export from nucleus • cell cycle • protein phosphorylation • positive regulation of protein serine/threonine kinase activity • activation of protein kinase activity • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • regulation of apoptotic process • MAPK cascade • GO:0072468 signal transduction • neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	92335	n/a
Ensembl	ENSG00000266173	n/a
UniProt	Q7RTN6	n/a
RefSeq (mRNA)	NM_001003786 NM_001003787 NM_001003788 NM_001165969 NM_001165970 NM_153335 NM_001363786 NM_001363787 NM_001363788 NM_001363789 NM_001363790 NM_001363791	n/a
RefSeq (protein)	NP_001003786 NP_001003787 NP_001003788 NP_001159441 NP_001159442 NP_699166 NP_001350715 NP_001350716 NP_001350717 NP_001350718 NP_001350719 NP_001350720	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STRADA yw STRADA a elwir hefyd yn STE20-related kinase adapter protein alpha a STE20-related kinase adaptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STRADA.

• LYK5
• PMSE
• Stlk
• STRAD
• NY-BR-96

Llyfryddiaeth

• "ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. ". PLoS Biol. 2009. PMID 19513107.
• "Analysis of the LKB1-STRAD-MO25 complex. ". J Cell Sci. 2004. PMID 15561763.
• "Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). ". Am J Med Genet A. 2016. PMID 27170158.
• "Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. ". Cancer Biol Ther. 2007. PMID 17921699.
• "Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.". Nat Struct Mol Biol. 2004. PMID 14730349.