STK4

STK4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3COM, 4NR2, 4OH8, 2JO8
Dynodwyr
Cyfenwau	STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
Dynodwyr allanol	OMIM: 604965 HomoloGene: 55965 GeneCards: STK4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein dimerization activity • protein homodimerization activity • transcription factor binding • protein serine/threonine kinase activator activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • magnesium ion binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • cytosol • nuclear body • GO:0009327 protein-containing complex Prosesau biolegol • regulation of cell differentiation involved in embryonic placenta development • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • phosphorylation • protein stabilization • hippo signaling • keratinocyte differentiation • positive regulation of peptidyl-serine phosphorylation • endocardium development • protein phosphorylation • primitive hemopoiesis • central nervous system development • GO:0035404 peptidyl-serine phosphorylation • GO:0000767 cell morphogenesis • positive regulation of apoptotic process • branching involved in blood vessel morphogenesis • protein autophosphorylation • positive regulation of protein binding • cell differentiation involved in embryonic placenta development • positive regulation of fat cell differentiation • negative regulation of organ growth • neural tube formation • negative regulation of canonical Wnt signaling pathway • GO:0072468 signal transduction • negative regulation of cell population proliferation • hepatocyte apoptotic process • GO:0097285 apoptotic process • positive regulation of protein serine/threonine kinase activity • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • positive regulation of vascular associated smooth muscle cell apoptotic process • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6789	n/a
Ensembl	ENSG00000101109	n/a
UniProt	Q13043	n/a
RefSeq (mRNA)	NM_006282 NM_001352385	n/a
RefSeq (protein)	NP_006273 NP_001339314	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STK4 yw STK4 a elwir hefyd yn Serine/threonine kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STK4.

• KRS2
• MST1
• YSK3

Llyfryddiaeth

• "[Expression of Hippo signaling pathway core element MST1 in acute leukemia patients and its significance]. ". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012. PMID 22739148.
• "The phenotype of human STK4 deficiency. ". Blood. 2012. PMID 22294732.
• "STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation. ". Clin Immunol. 2015. PMID 26117625.
• "The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells. ". J Immunol. 2015. PMID 26116501.
• "Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro.". Acta Biochim Biophys Sin (Shanghai). 2013. PMID 23419720.