STAT5B

STAT5B
Dynodwyr
Cyfenwau	STAT5B, STAT5, signal transducer and activator of transcription 5B, GHISID2
Dynodwyr allanol	OMIM: 604260 HomoloGene: 55718 GeneCards: STAT5B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signal transducer activity • glucocorticoid receptor binding • protein dimerization activity • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cytoplasm • cnewyllyn cell • cytosol Prosesau biolegol • positive regulation of natural killer cell differentiation • positive regulation of natural killer cell mediated cytotoxicity • regulation of steroid metabolic process • creatinine metabolic process • T cell differentiation in thymus • female pregnancy • cellular response to hormone stimulus • positive regulation of activated T cell proliferation • progesterone metabolic process • receptor signaling pathway via JAK-STAT • negative regulation of apoptotic process • Peyer's patch development • transcription, DNA-templated • GO:0072468 signal transduction • cellular response to growth factor stimulus • natural killer cell differentiation • response to interleukin-4 • sex differentiation • valine metabolic process • positive regulation of B cell differentiation • T cell homeostasis • creatine metabolic process • cellular response to epidermal growth factor stimulus • response to estradiol • positive regulation of inflammatory response • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • mast cell migration • positive regulation of mitotic cell cycle • lipid storage • development of secondary female sexual characteristics • fatty acid metabolic process • taurine metabolic process • succinate metabolic process • positive regulation of gamma-delta T cell differentiation • positive regulation of lymphocyte differentiation • regulation of multicellular organism growth • citrate metabolic process • positive regulation of cell population proliferation • oxaloacetate metabolic process • regulation of epithelial cell differentiation • positive regulation of natural killer cell proliferation • development of secondary male sexual characteristics • positive regulation of multicellular organism growth • GO:0009373 regulation of transcription, DNA-templated • allantoin metabolic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • luteinization • isoleucine metabolic process • negative regulation of erythrocyte differentiation • lactation • response to interleukin-15 • regulation of cell adhesion • 2-oxoglutarate metabolic process • response to interleukin-2 • growth hormone receptor signaling pathway via JAK-STAT • positive regulation of erythrocyte differentiation • peptidyl-tyrosine phosphorylation • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell population proliferation • response to peptide hormone Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6777	n/a
Ensembl	ENSG00000173757	n/a
UniProt	P51692	n/a
RefSeq (mRNA)	NM_012448	n/a
RefSeq (protein)	NP_036580	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT5B yw STAT5B a elwir hefyd yn Signal transducer and activator of transcription 5B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STAT5B.

• STAT5

Llyfryddiaeth

• "Interference of STAT 5b expression enhances the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. ". Oncol Rep. 2015. PMID 25997700.
• "STAT5 is Activated by Epidermal Growth Factor and Induces Proliferation and Invasion in Trophoblastic Cells. ". Reprod Sci. 2015. PMID 25862676.
• "Phospho-STAT5B Expression Is a Prognostic Marker for Merkel Cell Carcinoma. ". Anticancer Res. 2017. PMID 28476799.
• "Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion. ". Oncol Rep. 2016. PMID 27035235.
• "STAT5B mutations in heterozygous state have negative impact on height: another clue in human stature heritability.". Eur J Endocrinol. 2015. PMID 26034074.