STAT3 Dynodwyr Cyfenwau STAT3 Dynodwyr allanol OMIM: 102582 HomoloGene: 7960 GeneCards: STAT3 Ontoleg y genyn Gweithrediad moleciwlaidd • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • protein phosphatase binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • DNA binding • sequence-specific DNA binding • chromatin DNA binding • protein homodimerization activity • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signal transducer activity • transcription factor binding • CCR5 chemokine receptor binding • glucocorticoid receptor binding Cydrannau o'r gell • cytoplasm • mitocondria • cnewyllyn cell • Cellbilen • nucleoplasm • RNA polymerase II transcription regulator complex • mitochondrial inner membrane • cytosol • GO:0097483, GO:0097481 postsynaptic density • Schaffer collateral - CA1 synapse • glutamatergic synapse • transcription regulator complex Prosesau biolegol • negative regulation of glycolytic process • protein import into nucleus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • response to organic substance • GO:1905618 positive regulation of gene silencing by miRNA • radial glial cell differentiation • stem cell population maintenance • cellular response to hormone stimulus • regulation of mitochondrial membrane permeability • growth hormone receptor signaling pathway • miRNA-mediated gene silencing by inhibition of translation • eye photoreceptor cell differentiation • positive regulation of metalloendopeptidase activity • temperature homeostasis • cell population proliferation • response to leptin • response to ethanol • positive regulation of Notch signaling pathway • negative regulation of cell population proliferation • response to cytokine • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • negative regulation of cell death • transcription, DNA-templated • positive regulation of growth factor dependent skeletal muscle satellite cell proliferation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of hydrogen peroxide biosynthetic process • energy homeostasis • GO:0022415 viral process • negative regulation of neuron death • sexual reproduction • phosphorylation • leptin-mediated signaling pathway • GO:1904579 cellular response to organic cyclic compound • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of feeding behavior • nervous system development • positive regulation of ATP biosynthetic process • intracellular receptor signaling pathway • acute-phase response • negative regulation of neuron migration • receptor signaling pathway via JAK-STAT • response to estradiol • GO:1904578 response to organic cyclic compound • eating behavior • somatic stem cell population maintenance • regulation of multicellular organism growth • GO:0010260 heneiddio • response to peptide hormone • cellular response to leptin stimulus • regulation of cell cycle • astrocyte differentiation • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • growth hormone receptor signaling pathway via JAK-STAT • GO:1901313 positive regulation of gene expression • negative regulation of stem cell differentiation • positive regulation of cell population proliferation • mRNA transcription by RNA polymerase II • inflammatory response • positive regulation of erythrocyte differentiation • T-helper 17 cell lineage commitment • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of tyrosine phosphorylation of STAT protein • interleukin-15-mediated signaling pathway • interleukin-7-mediated signaling pathway • positive regulation of angiogenesis • positive regulation of vascular endothelial cell proliferation • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-23-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • cellular response to cytokine stimulus • interleukin-9-mediated signaling pathway • modulation of chemical synaptic transmission • postsynapse to nucleus signaling pathway • negative regulation of autophagy • positive regulation of cell migration • positive regulation of NF-kappaB transcription factor activity • defense response • regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT3 yw STAT3 a elwir hefyd yn Signal transducer and activator of transcription 3 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STAT3.
"The relationship between microRNAs and the STAT3-related signaling pathway in cancer. ". Tumour Biol . 2017. PMID 28859543 . "Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis. ". PLoS One . 2017. PMID 28797050 . "Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma. ". Int J Cancer . 2017. PMID 28646535 . "Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma. ". Tumour Biol . 2017. PMID 28618941 . "Gallic acid against hepatocellular carcinoma: An integrated scheme of the potential mechanisms of action from in vivo study. ". Tumour Biol . 2017. PMID 28618930 . 
