STAT1 Dynodwyr Cyfenwau STAT1 Dynodwyr allanol OMIM: 600555 HomoloGene: 21428 GeneCards: STAT1 Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000983 RNA polymerase II general transcription initiation factor activity • signal transducer activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • tumor necrosis factor receptor binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • cadherin binding • histone acetyltransferase binding • GO:0031493 histone binding • ubiquitin-like protein ligase binding • promoter-specific chromatin binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • CCR5 chemokine receptor binding • protein phosphatase 2A binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nucleoplasm • nucleolus • perinuclear region of cytoplasm • cnewyllyn cell • cytosol • axon • dendrite • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • metanephric mesenchymal cell proliferation involved in metanephros development • GO:0009373 regulation of transcription, DNA-templated • cellular response to interferon-beta • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • tumor necrosis factor-mediated signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • renal tubule development • response to interferon-beta • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of endothelial cell proliferation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • positive regulation of mesenchymal cell proliferation • negative regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of angiogenesis • negative regulation by virus of viral protein levels in host cell • GO:0022415 viral process • endothelial cell migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • macrophage derived foam cell differentiation • positive regulation of erythrocyte differentiation • type I interferon signaling pathway • cellular response to interferon-gamma • positive regulation of defense response to virus by host • positive regulation of interferon-alpha production • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • defense response to virus • interferon-gamma-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to nutrient • blood circulation • positive regulation of cell population proliferation • response to mechanical stimulus • GO:1904578 response to organic cyclic compound • cellular response to insulin stimulus • response to cytokine • response to hydrogen peroxide • response to peptide hormone • positive regulation of smooth muscle cell proliferation • response to cAMP • positive regulation of nitric-oxide synthase biosynthetic process • cellular response to cytokine stimulus • GO:1904579 cellular response to organic cyclic compound • positive regulation of transcription of Notch receptor target • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • interleukin-9-mediated signaling pathway • defense response • regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn STAT1 yw STAT1 a elwir hefyd yn Signal transducer and activator of transcription 1-alpha/beta a Signal transducer and activator of transcription 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q32.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn STAT1.
CANDF7
IMD31A
IMD31B
IMD31C
ISGF-3
STAT91
"Quantitative specificity of STAT1 and several variants. ". Nucleic Acids Res . 2017. PMID 28510715 . "Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation. ". J Biol Chem . 2017. PMID 28258222 . "Gain-of-function STAT1 mutations are associated with intracranial aneurysms. ". Clin Immunol . 2017. PMID 28161409 . "Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. ". J Allergy Clin Immunol . 2017. PMID 28069426 . "A heterozygous dominant-negative mutation in the coiled-coil domain of STAT1 is the cause of autosomal-dominant Mendelian susceptibility to mycobacterial diseases. ". Clin Immunol . 2017. PMID 27856304 . 
