SSB

SSB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OWX, 1S79, 1S7A, 1YTY, 1ZH5, 2VOD, 2VON, 2VOO, 2VOP
Dynodwyr
Cyfenwau	SSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La
Dynodwyr allanol	OMIM: 109090 HomoloGene: 2366 GeneCards: SSB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • mRNA binding • nucleic acid binding • tRNA binding • RNA binding • poly(U) RNA binding • protein homodimerization activity • sequence-specific mRNA binding Cydrannau o'r gell • cnewyllyn cell • cytoplasm • ribonucleoprotein complex Prosesau biolegol • GO:0033168, GO:0036404, GO:1902360 RNA processing • histone mRNA metabolic process • protein localization to cytoplasmic stress granule • tRNA modification • IRES-dependent viral translational initiation • tRNA 5'-leader removal • tRNA export from nucleus • tRNA processing • tRNA 3'-end processing • nuclear histone mRNA catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6741	n/a
Ensembl	ENSG00000138385	n/a
UniProt	P05455	n/a
RefSeq (mRNA)	NM_003142 NM_001294145	n/a
RefSeq (protein)	NP_001281074 NP_003133	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SSB yw SSB a elwir hefyd yn Sjogren syndrome antigen B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SSB.

• La
• LARP3
• La/SSB

Llyfryddiaeth

• "Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR. ". J Immunol. 2015. PMID 25582858.
• "Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation. ". Nucleic Acids Res. 2015. PMID 25520193.
• "Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif. ". Biochemistry. 2016. PMID 27959512.
• "The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway. ". Mol Cell. 2016. PMID 27345152.
• "SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.". PLoS One. 2016. PMID 27224031.