SRY

SRY
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HRY, 1HRZ, 1J46, 1J47, 2GZK
Dynodwyr
Cyfenwau	SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
Dynodwyr allanol	OMIM: 480000 HomoloGene: 48168 GeneCards: SRY
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • calmodulin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nuclear speck • nucleoplasm • cnewyllyn cell Prosesau biolegol • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • sex differentiation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of male gonad development • male sex determination • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • central nervous system development • GO:1901313 positive regulation of gene expression • neuron differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6736	n/a
Ensembl	ENSG00000184895	n/a
UniProt	Q05066	Q9ERV8
RefSeq (mRNA)	NM_003140	n/a
RefSeq (protein)	NP_003131	NP_036904
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SRY yw SRY a elwir hefyd yn Sex determining region Y (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom Y dynol, band Yp11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SRY.

• TDF
• TDY
• SRXX1
• SRXY1

Llyfryddiaeth

• "An infertile 45,X male with a SRY-bearing chromosome 13: a clinical case report and literature review. ". J Assist Reprod Genet. 2015. PMID 25374395.
• "Sex-determination gene SRY potentially associates with poor prognosis but not sex bias in hepatocellular carcinoma. ". Dig Dis Sci. 2015. PMID 25274159.
• "Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box. ". J Biol Chem. 2014. PMID 25258310.
• "Transient neuroprotection by SRY upregulation in dopamine cells following injury in males. ". Endocrinology. 2014. PMID 24708242.
• "Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold.". Proc Natl Acad Sci U S A. 2013. PMID 24003159.