SRI

SRI
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JUO, 2JC2, 4U8D, 4UPG, 4USL
Dynodwyr
Cyfenwau	SRI, CP-22, CP22, SCN, V19, sorcin
Dynodwyr allanol	OMIM: 182520 HomoloGene: 37736 GeneCards: SRI
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • transmembrane transporter binding • calcium channel regulator activity • metal ion binding • calcium-dependent cysteine-type endopeptidase activity • protease binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • identical protein binding • signaling receptor binding Cydrannau o'r gell • axon terminus • dendritic spine neck • fesigl • cytosol • endoplasmic reticulum membrane • bilen • T-tubule • Cellbilen • intracellular anatomical structure • sarcoplasmic reticulum • nucleoplasm • smooth endoplasmic reticulum • axon • chromaffin granule membrane • Z disc • mitocondria • sarcoplasmic reticulum membrane • extracellular exosome • cytoplasm Prosesau biolegol • regulation of calcium ion transport • regulation of heart contraction • cytoplasmic sequestering of transcription factor • muscle organ development • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of heart rate • proteolysis • negative regulation of ryanodine-sensitive calcium-release channel activity • regulation of cardiac muscle cell contraction • heart development • intracellular sequestering of iron ion • regulation of striated muscle contraction • negative regulation of transcription regulatory region DNA binding • regulation of high voltage-gated calcium channel activity • action potential • positive regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of cell communication by electrical coupling • regulation of cell communication by electrical coupling involved in cardiac conduction • regulation of relaxation of muscle • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium ion transport • GO:0072468 signal transduction • negative regulation of cardiac muscle contraction • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6717	n/a
Ensembl	ENSG00000075142	n/a
UniProt	P30626	n/a
RefSeq (mRNA)	NM_001256891 NM_001256892 NM_003130 NM_198901	n/a
RefSeq (protein)	NP_001243820 NP_001243821 NP_003121 NP_944490	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SRI yw SRI a elwir hefyd yn Sorcin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SRI.

• SCN
• V19
• CP22
• CP-22

Llyfryddiaeth

• "Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study. ". Inflamm Res. 2014. PMID 25001342.
• "Reversing effect of sorcin in the drug resistance of human nasopharyngeal carcinoma. ". Anat Rec (Hoboken). 2014. PMID 24376145.
• "shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines. ". Int J Clin Exp Pathol. 2015. PMID 26045737.
• "Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer. ". Cell Biochem Biophys. 2015. PMID 25567655.
• "Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.". Molecules. 2014. PMID 25197934.