SQSTM1

SQSTM1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9
Dynodwyr
Cyfenwau	SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV
Dynodwyr allanol	OMIM: 601530 HomoloGene: 31202 GeneCards: SQSTM1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • receptor tyrosine kinase binding; • zinc ion binding; • SH2 domain binding; • metal ion binding; • protein serine/threonine kinase activity; • K63-linked polyubiquitin modification-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein kinase binding; • protein kinase C binding; • ubiquitin binding; • enzyme binding; • ubiquitin protein ligase binding; • ionotropic glutamate receptor binding;
Cydrannau o'r gell	• cytoplasm; • endosome; • PML body; • late endosome; • P-body; • phagophore assembly site; • nucleoplasm; • aggresome; • autophagosome; • amphisome; • Reticwlwm endoplasmig; • inclusion body; • lysosome; • sperm midpiece; • extracellular exosome; • GO:0016023 cytoplasmic vesicle; • cnewyllyn cell; • cytosol; • intracellular membrane-bounded organelle; • autolysosome; • mitocondria; • sarcomere; • Lewy body;
Prosesau biolegol	• GO:0097285 apoptotic process; • GO:0034613 protein localization; • cell differentiation; • positive regulation of protein phosphorylation; • GO:0007243 intracellular signal transduction; • ubiquitin-dependent protein catabolic process; • regulation of mitochondrion organization; • protein heterooligomerization; • immune system process; • response to stress; • regulation of Ras protein signal transduction; • negative regulation of apoptotic process; • autophagy; • endosomal transport; • regulation of protein complex stability; • autophagy of mitochondrion; • positive regulation of apoptotic process; • regulation of I-kappaB kinase/NF-kappaB signaling; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:1901227 negative regulation of transcription by RNA polymerase II; • protein phosphorylation; • mitophagy; • response to mitochondrial depolarisation; • macroautophagy; • endosome organization; • protein localization to perinuclear region of cytoplasm; • response to ischemia; • mitochondrion organization; • aggrephagy; • selective autophagy; • interleukin-1-mediated signaling pathway; • positive regulation of long-term synaptic potentiation; • positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologau
	8878
	n/a
	ENSG00000161011; ENSG00000284099
	n/a
	Q13501
	n/a
	NM_001142298; NM_001142299; NM_003900
	n/a
	NP_001135770; NP_001135771; NP_003891
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SQSTM1 yw SQSTM1 a elwir hefyd yn Sequestosome 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q35.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SQSTM1.

p60
p62
A170
DMRV
OSIL
PDB3
ZIP3
p62B
NADGP
FTDALS3

Llyfryddiaeth[golygu | golygu cod]

"p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. ". Biochim Biophys Acta. 2017. PMID 28433685.
"Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. ". PLoS One. 2017. PMID 28222108.
"p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis. ". Carcinogenesis. 2017. PMID 28968743.
"Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. ". J Biol Chem. 2017. PMID 28724634.
"Autophagy upregulation ameliorates cell injury in Sequestosome 1 knockout podocytes in vitro.". Biochem Biophys Res Commun. 2017. PMID 28600173.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] SQSTM1 - Cronfa NCBI

[1]

[2]