SPTBN1

SPTBN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AA2, 1BKR, 3EDV
Dynodwyr
Cyfenwau	SPTBN1, ELF, HEL102, SPTB2, betaSpII, spectrin beta, non-erythrocytic 1, DDISBA
Dynodwyr allanol	OMIM: 182790 HomoloGene: 2354 GeneCards: SPTBN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calmodulin binding • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding • ankyrin binding • GTPase binding • actin binding • phospholipid binding • GO:0032403 protein-containing complex binding • RNA binding • cadherin binding Cydrannau o'r gell • cytoplasm • M band • cytosol • spectrin • bilen • cortical cytoskeleton • Cellbilen • cuticular plate • nucleolus • axolemma • spectrin-associated cytoskeleton • extracellular exosome • Cytosgerbwd • cnewyllyn cell • GO:0097483, GO:0097481 postsynaptic density • GO:0009327 protein-containing complex • postsynapse • glutamatergic synapse Prosesau biolegol • common-partner SMAD protein phosphorylation • mitotic cytokinesis • MAPK cascade • axon guidance • endoplasmic reticulum to Golgi vesicle-mediated transport • positive regulation of protein localization to plasma membrane • actin filament capping • plasma membrane organization • membrane assembly • regulation of protein localization to plasma membrane • Golgi to plasma membrane protein transport • cytoskeleton organization • protein localization to plasma membrane • regulation of molecular function • regulation of SMAD protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6711	n/a
Ensembl	ENSG00000115306	n/a
UniProt	Q01082	n/a
RefSeq (mRNA)	NM_003128 NM_178313	n/a
RefSeq (protein)	NP_003119 NP_842565	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPTBN1 yw SPTBN1 a elwir hefyd yn Spectrin beta, non-erythrocytic 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p16.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPTBN1.

• ELF
• SPTB2
• HEL102
• betaSpII

Llyfryddiaeth

• "A novel isoform of beta-spectrin II localizes to cerebellar Purkinje-cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin. ". J Mol Neurosci. 2001. PMID 11665863.
• "Structural comparisons of calponin homology domains: implications for actin binding. ". Structure. 1998. PMID 9817844.
• "Candidate Biomarkers for HPV-Negative Head and Neck Cancer Identified via Gene Expression Barcode Analysis. ". Otolaryngol Head Neck Surg. 2016. PMID 27095047.
• "Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer. ". Histol Histopathol. 2010. PMID 20886430.
• "Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.". Oncogene. 2007. PMID 17546056.