SPRY2

SPRY2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3BUM, 3OB1
Dynodwyr
Cyfenwau	SPRY2, hIGAN3, sprouty RTK signaling antagonist 2
Dynodwyr allanol	OMIM: 602466 HomoloGene: 4267 GeneCards: SPRY2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine kinase inhibitor activity • protein serine/threonine kinase activator activity • GO:0001948, GO:0016582 protein binding • protein kinase binding Cydrannau o'r gell • cytoplasm • cytosol • cell projection • bilen • Cellbilen • ruffle membrane • microtubule • Cytosgerbwd • cnewyllyn cell • microtubule cytoskeleton Prosesau biolegol • cell fate commitment • negative regulation of neurotrophin TRK receptor signaling pathway • positive regulation of protein kinase B signaling • negative regulation of epidermal growth factor receptor signaling pathway • lung morphogenesis • lung development • bud elongation involved in lung branching • negative regulation of peptidyl-threonine phosphorylation • lung growth • negative regulation of apoptotic process • sensory perception of sound • positive regulation of peptidyl-serine phosphorylation • negative regulation of Ras protein signal transduction • multicellular organism development • negative regulation of fibroblast growth factor receptor signaling pathway • GO:1901313 positive regulation of gene expression • GO:0034259 negative regulation of GTPase activity • regulation of cell population proliferation • regulation of signal transduction • negative regulation of MAP kinase activity • inner ear morphogenesis • respiratory system development • establishment of mitotic spindle orientation • negative regulation of cell projection organization • positive regulation of ERK1 and ERK2 cascade • regulation of cell differentiation • branching morphogenesis of an epithelial tube • negative regulation of cell population proliferation • positive regulation of protein serine/threonine kinase activity • positive regulation of cell migration • negative regulation of ERK1 and ERK2 cascade • cellular response to leukemia inhibitory factor • negative regulation of angiogenesis • cellular response to vascular endothelial growth factor stimulus • negative regulation of vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10253	n/a
Ensembl	ENSG00000136158	n/a
UniProt	O43597	n/a
RefSeq (mRNA)	NM_005842 NM_001318536 NM_001318537 NM_001318538	n/a
RefSeq (protein)	NP_001305465 NP_001305466 NP_001305467 NP_005833	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPRY2 yw SPRY2 a elwir hefyd yn Sprouty RTK signaling antagonist 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPRY2.

• IGAN3
• hSPRY2

Llyfryddiaeth

• "Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals. ". Mol Immunol. 2015. PMID 26265114.
• "Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. ". Mol Cancer Res. 2015. PMID 25934697.
• "Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways. ". PLoS One. 2016. PMID 27415760.
• "Sprouty2 regulates proliferation and survival of multiple myeloma by inhibiting activation of the ERK1/2 pathway in vitro and in vivo. ". Exp Hematol. 2016. PMID 27016275.
• "Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells.". J Cell Biochem. 2016. PMID 26727965.