SPOP

SPOP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CR2, 3HQH, 3HQI, 3HQL, 3HQM, 3HTM, 3HU6, 3IVB, 3IVQ, 3IVV, 4EOZ, 4HS2, 4J8Z, 4O1V
Dynodwyr
Cyfenwau	SPOP, BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
Dynodwyr allanol	OMIM: 602650 HomoloGene: 68354 GeneCards: SPOP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding Cydrannau o'r gell • Cul3-RING ubiquitin ligase complex • nuclear speck • cnewyllyn cell • nucleoplasm • cytoplasm • SCF ubiquitin ligase complex Prosesau biolegol • protein ubiquitination • regulation of proteolysis • GO:1901227 negative regulation of transcription by RNA polymerase II • glucose homeostasis • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of DNA-binding transcription factor activity • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • positive regulation of type B pancreatic cell apoptotic process • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8405	n/a
Ensembl	ENSG00000121067	n/a
UniProt	O43791	n/a
RefSeq (mRNA)	NM_001007226 NM_001007227 NM_001007228 NM_001007229 NM_001007230 NM_003563 NM_001370730 NM_001370731 NM_001370732	n/a
RefSeq (protein)	NP_001007227 NP_001007228 NP_001007229 NP_001007230 NP_001007231 NP_003554 NP_001357659 NP_001357660 NP_001357661	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPOP yw SPOP a elwir hefyd yn Speckle type BTB/POZ protein a Speckle-type POZ protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPOP.

• TEF2
• BTBD32

Llyfryddiaeth

• "SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. ". Cell Rep. 2015. PMID 26527005.
• "Relationship between SPOP mutation and breast cancer in Chinese population. ". Genet Mol Res. 2015. PMID 26505385.
• "Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. ". Nat Med. 2017. PMID 28805821.
• "Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. ". Nat Med. 2017. PMID 28805820.
• "SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma.". Int J Oncol. 2016. PMID 27572476.