SPINT1

SPINT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YC0, 2MSX, 4ISL, 4ISN, 4ISO, 5EZD
Dynodwyr
Cyfenwau	SPINT1, HAI, HAI1, MANSC2, serine peptidase inhibitor, Kunitz type 1
Dynodwyr allanol	OMIM: 605123 HomoloGene: 9653 GeneCards: SPINT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • extracellular region • extracellular exosome • bilen • extracellular space • Cellbilen Prosesau biolegol • negative regulation of peptidase activity • negative regulation of endopeptidase activity • neural tube closure • embryonic placenta development • extracellular matrix organization • positive regulation of glial cell differentiation • branching involved in labyrinthine layer morphogenesis • placenta blood vessel development • cellular response to BMP stimulus • negative regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6692	n/a
Ensembl	ENSG00000166145	n/a
UniProt	O43278	n/a
RefSeq (mRNA)	NM_001032367 NM_003710 NM_181642 NM_001386873 NM_001386874 NM_001386875	n/a
RefSeq (protein)	NP_001027539 NP_003701 NP_857593	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPINT1 yw SPINT1 a elwir hefyd yn Serine peptidase inhibitor, Kunitz type 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPINT1.

• HAI
• HAI1
• MANSC2

Llyfryddiaeth

• "Expression of hepatocyte growth factor activator inhibitor-1 (HAI-1) gene in prostate cancer: clinical and biological significance. ". J BUON. 2014. PMID 24659667.
• "Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model. ". Cancer Sci. 2014. PMID 24147538.
• "The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition. ". J Biol Chem. 2017. PMID 28348076.
• "Reprogramming Nurse-like Cells with Interferon γ to Interrupt Chronic Lymphocytic Leukemia Cell Survival. ". J Biol Chem. 2016. PMID 27226587.
• "The solution structure of the MANEC-type domain from hepatocyte growth factor activator inhibitor-1 reveals an unexpected PAN/apple domain-type fold.". Biochem J. 2015. PMID 25510835.