SPINK5

SPINK5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H0Z, 1HDL, 1UUC, 1UVF, 1UVG
Dynodwyr
Cyfenwau	SPINK5, LEKTI, LETKI, NETS, NS, VAKTI, serine peptidase inhibitor, Kazal type 5, serine peptidase inhibitor Kazal type 5
Dynodwyr allanol	OMIM: 605010 HomoloGene: 4987 GeneCards: SPINK5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • cytoplasm • cytosol • endoplasmic reticulum membrane • cell cortex • Reticwlwm endoplasmig • perinuclear region of cytoplasm • epidermal lamellar body • extracellular region • intracellular membrane-bounded organelle Prosesau biolegol • epidermal cell differentiation • negative regulation of proteolysis • negative regulation of serine-type peptidase activity • negative regulation of peptidase activity • epithelial cell differentiation • hair cell differentiation • extracellular matrix organization • negative regulation of antibacterial peptide production • negative regulation of immune response • regulation of cell adhesion • negative regulation of angiogenesis • negative regulation of serine-type endopeptidase activity • regulation of T cell differentiation • cornification • regulation of timing of anagen Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11005	n/a
Ensembl	ENSG00000133710	n/a
UniProt	Q9NQ38	n/a
RefSeq (mRNA)	NM_001127698 NM_001127699 NM_006846	n/a
RefSeq (protein)	NP_001121170 NP_001121171 NP_006837	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPINK5 yw SPINK5 a elwir hefyd yn Serine peptidase inhibitor, Kazal type 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPINK5.

• NS
• NETS
• LEKTI
• LETKI
• VAKTI

Llyfryddiaeth

• "Molecular analysis of a series of Israeli families with Comèl-Netherton syndrome. ". Dermatology. 2014. PMID 24577329.
• "Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation. ". J Invest Dermatol. 2014. PMID 24390132.
• "Intrafamily and Interfamilial Phenotype Variation and Immature Immunity in Patients With Netherton Syndrome and Finnish SPINK5 Founder Mutation. ". JAMA Dermatol. 2016. PMID 26865388.
• "New mutation leading to the full variety of typical features of the Netherton syndrome. ". J Dtsch Dermatol Ges. 2015. PMID 26031502.
• "Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy.". Biol Chem. 2014. PMID 25153381.