SPDEF

SPDEF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DKX
Dynodwyr
Cyfenwau	SPDEF, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
Dynodwyr allanol	OMIM: 608144 HomoloGene: 8231 GeneCards: SPDEF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell Prosesau biolegol • multicellular organism development • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of cell fate commitment • lung goblet cell differentiation • intestinal epithelial cell development • transcription, DNA-templated • positive regulation of cell fate commitment • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of apoptotic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25803	n/a
Ensembl	ENSG00000124664	n/a
UniProt	O95238	n/a
RefSeq (mRNA)	NM_001252294 NM_012391	n/a
RefSeq (protein)	NP_001239223 NP_036523	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPDEF yw SPDEF a elwir hefyd yn SAM pointed domain containing ETS transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPDEF.

• PDEF
• bA375E1.3

Llyfryddiaeth

• "Prostate-derived ets factor represses tumorigenesis and modulates epithelial-to-mesenchymal transition in bladder carcinoma cells. ". Cancer Lett. 2016. PMID 26965996.
• "PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. ". Cancer Cell. 2013. PMID 23764000.
• "Prostate-derived Ets factor, an oncogenic driver in breast cancer. ". Tumour Biol. 2017. PMID 28468594.
• "Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. ". Am J Physiol Lung Cell Mol Physiol. 2017. PMID 28011616.
• "Signatures of prostate-derived Ets factor (PDEF) in cancer.". Tumour Biol. 2016. PMID 27612480.