SPARC

SPARC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BMO, 1NUB, 1SRA, 2V53
Dynodwyr
Cyfenwau	SPARC, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
Dynodwyr allanol	OMIM: 182120 HomoloGene: 31132 GeneCards: SPARC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • extracellular matrix binding • collagen binding • extracellular matrix structural constituent Cydrannau o'r gell • cytoplasm • platelet alpha granule • endocytic vesicle lumen • nuclear matrix • Cellbilen • intracellular anatomical structure • basement membrane • cell surface • platelet alpha granule membrane • mitocondria • platelet alpha granule lumen • cnewyllyn cell • extracellular space • fesigl • extracellular region • GO:0005578 extracellular matrix • synapse • collagen-containing extracellular matrix • glutamatergic synapse Prosesau biolegol • response to cytokine • response to cadmium ion • ossification • lung development • cellular response to growth factor stimulus • response to peptide hormone • platelet degranulation • extracellular matrix organization • response to L-ascorbic acid • response to glucocorticoid • wound healing • receptor-mediated endocytosis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell migration • response to calcium ion • response to gravity • heart development • response to lipopolysaccharide • response to lead ion • regulation of cell population proliferation • negative regulation of angiogenesis • inner ear development • regulation of cell morphogenesis • response to cAMP • response to ethanol • bone development • GO:0072468 signal transduction • pigmentation • GO:1904739 regulation of synapse organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6678	n/a
Ensembl	ENSG00000113140	n/a
UniProt	P09486	n/a
RefSeq (mRNA)	NM_003118 NM_001309443 NM_001309444	n/a
RefSeq (protein)	NP_001296372 NP_001296373 NP_003109	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPARC yw SPARC a elwir hefyd yn Secreted protein acidic and cysteine rich (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPARC.

• ON
• OI17
• BM-40

Llyfryddiaeth

• "Clinical significance of SPARC in esophageal squamous cell carcinoma. ". Biochem Biophys Res Commun. 2017. PMID 28818666.
• "The relationship between SPARC expression in primary tumor and metastatic lymph node of resected pancreatic cancer patients and patients' survival. ". Hepatobiliary Pancreat Dis Int. 2017. PMID 28119265.
• "In phyllodes tumors of the breast expression of SPARC (osteonectin/BM40) mRNA by in situ hybridization correlates with protein expression by immunohistochemistry and is associated with tumor progression. ". Virchows Arch. 2017. PMID 27909812.
• "The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease. ". Br J Pharmacol. 2017. PMID 27759879.
• "Prognostic Value of SPARC in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis.". PLoS One. 2016. PMID 26731428.