SP3

SP3
Dynodwyr
Cyfenwau	SP3, SPR2, Sp3 transcription factor
Dynodwyr allanol	OMIM: 601804 HomoloGene: 7952 GeneCards: SP3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • chromatin binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • metal ion binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • double-stranded DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • PML body • transcription repressor complex • cnewyllyn cell • nucleoplasm • protein-DNA complex Prosesau biolegol • megakaryocyte differentiation • GO:0009373 regulation of transcription, DNA-templated • ossification • lung development • embryonic placenta development • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • monocyte differentiation • protein sumoylation • transcription, DNA-templated • embryonic skeletal system development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • embryonic process involved in female pregnancy • T cell differentiation • granulocyte differentiation • embryonic camera-type eye morphogenesis • trophectodermal cell differentiation • enucleate erythrocyte differentiation • erythrocyte differentiation • definitive hemopoiesis • liver development • B cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • natural killer cell differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6670	n/a
Ensembl	ENSG00000172845	n/a
UniProt	Q02447 Q86TP0	n/a
RefSeq (mRNA)	NM_003111 NM_001017371 NM_001172712	n/a
RefSeq (protein)	NP_001017371 NP_001166183 NP_003102 NP_003102.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SP3 yw SP3 a elwir hefyd yn SP3 protein a Sp3 transcription factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SP3.

• SPR2

Llyfryddiaeth

• "[Deficient mRNA expression of specific protein 3 gene in peripheral blood mononuclear cells from patients with multiple sclerosis]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008. PMID 18393243.
• "Transcriptional regulation of the 5'-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F. ". Biochim Biophys Acta. 2008. PMID 18342022.
• "Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene. ". FEBS J. 2011. PMID 21235713.
• "Effect of SP3 silencing on cytokeratin expression pattern in HPV-positive cells. ". Int J Immunopathol Pharmacol. 2009. PMID 19309563.
• "Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness.". PLoS One. 2009. PMID 19212434.