SORT1

SORT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7
Dynodwyr
Cyfenwau	SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
Dynodwyr allanol	OMIM: 602458 HomoloGene: 136097 GeneCards: SORT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nerve growth factor receptor activity • neurotensin receptor activity, non-G protein-coupled • nerve growth factor binding • GO:0001948, GO:0016582 protein binding • enzyme binding Cydrannau o'r gell • integral component of membrane • endosome • Golgi apparatus • nuclear membrane • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • Cellbilen • Golgi cisterna membrane • cell surface • lysosomal membrane • neuronal cell body • dendrite • early endosome • Reticwlwm endoplasmig • perinuclear region of cytoplasm • clathrin-coated pit • trans-Golgi network transport vesicle • lysosome • endosome membrane • clathrin-coated vesicle • cnewyllyn cell • cytosol • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle Prosesau biolegol • G protein-coupled receptor signaling pathway • cell differentiation • myotube differentiation • negative regulation of fat cell differentiation • endocytosis • neurotrophin TRK receptor signaling pathway • ossification • endosome transport via multivesicular body sorting pathway • vesicle organization • endosome to lysosome transport • Golgi to endosome transport • positive regulation of epithelial cell apoptotic process • multicellular organism development • response to insulin • plasma membrane to endosome transport • regulation of gene expression • negative regulation of lipoprotein lipase activity • glucose import • neuropeptide signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • nerve growth factor signaling pathway • post-Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6272	n/a
Ensembl	ENSG00000134243	n/a
UniProt	Q99523	n/a
RefSeq (mRNA)	NM_001205228 NM_002959	n/a
RefSeq (protein)	NP_001192157 NP_002950	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SORT1 yw SORT1 a elwir hefyd yn Sortilin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.3|1p21.3-p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SORT1.

• NT3
• Gp95
• NTR3
• LDLCQ6

Llyfryddiaeth

• "Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. ". Atherosclerosis. 2016. PMID 27085161.
• "SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. ". ASN Neuro. 2015. PMID 26297037.
• "Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. ". Arterioscler Thromb Vasc Biol. 2017. PMID 28279970.
• "Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients. ". J Affect Disord. 2017. PMID 27838145.
• "Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.". Exp Gerontol. 2016. PMID 27612602.