SORBS1

SORBS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DL3, 2ECZ, 2LJ0, 2MOX, 2O2W, 2O31, 2O9S, 2O9V, 4LN2, 4LNP
Dynodwyr
Cyfenwau	SORBS1, CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1, sorbin and SH3 domain containing 1
Dynodwyr allanol	OMIM: 605264 HomoloGene: 83252 GeneCards: SORBS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin receptor binding • cytoskeletal protein binding • GO:0001948, GO:0016582 protein binding • actin binding Cydrannau o'r gell • cytosol • centrosome • bilen • focal adhesion • nuclear matrix • adherens junction • Cellbilen • stress fiber • cell junction • zonula adherens • membrane raft • Cytosgerbwd • cnewyllyn cell • insulin receptor complex • cytoplasm Prosesau biolegol • positive regulation of glucose import • positive regulation of glycogen biosynthetic process • muscle contraction • positive regulation of lipid biosynthetic process • actin filament organization • stress fiber assembly • focal adhesion assembly • cellular response to insulin stimulus • cell-matrix adhesion • positive regulation of signal transduction • positive regulation of protein localization to plasma membrane • GO:1901047 insulin receptor signaling pathway • GO:1903106 positive regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10580	n/a
Ensembl	ENSG00000095637	n/a
UniProt	Q9BX66	n/a
RefSeq (mRNA)	NM_001034954 NM_001034955 NM_001034956 NM_001034957 NM_001290294 NM_001290295 NM_001290296 NM_001290297 NM_001290298 NM_006434 NM_015385 NM_024991 NM_001377197 NM_001377198 NM_001377199 NM_001377200 NM_001377201 NM_001377202 NM_001377203 NM_001377204 NM_001377205 NM_001377206 NM_001377207 NM_001377208 NM_001377209 NM_001384447 NM_001384448 NM_001384449 NM_001384450 NM_001384451 NM_001384452 NM_001384453 NM_001384454 NM_001384455 NM_001384456 NM_001384457 NM_001384458 NM_001384459 NM_001384460 NM_001384461 NM_001384462 NM_001384463 NM_001384464 NM_001384465	n/a
RefSeq (protein)	NP_001030126 NP_001030127 NP_001030128 NP_001030129 NP_001277223 NP_001277224 NP_001277225 NP_001277226 NP_001277227 NP_006425 NP_056200 NP_079267 NP_001364126 NP_001364127 NP_001364128 NP_001364129 NP_001364130 NP_001364131 NP_001364132 NP_001364133 NP_001364134 NP_001364135 NP_001364136 NP_001364137 NP_001364138	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SORBS1 yw SORBS1 a elwir hefyd yn Sorbin and SH3 domain containing 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SORBS1.

• CAP
• FLAF2
• R85FL
• SH3D5
• SORB1
• SH3P12

Llyfryddiaeth

• "A novel isoform of Cbl-associated protein that binds protein kinase A. ". Biochim Biophys Acta. 2005. PMID 15716063.
• "Frequency of the T228A polymorphism in the SORBS1 gene in children with premature pubarche and in adolescent girls with hyperandrogenism. ". Fertil Steril. 2003. PMID 12849814.
• "Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study. ". Medicine (Baltimore). 2016. PMID 26962801.
• "SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes. ". Diabetologia. 2015. PMID 25476525.
• "Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study.". Eur J Neurol. 2008. PMID 18394047.