SOD2

SOD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AP5, 1AP6, 1EM1, 1JA8, 1LUV, 1LUW, 1MSD, 1N0J, 1N0N, 1PL4, 1PM9, 1QNM, 1SZX, 1VAR, 1XDC, 1XIL, 1ZSP, 1ZTE, 1ZUQ, 2ADP, 2ADQ, 2GDS, 2P4K, 2QKA, 2QKC, 3C3S, 3C3T
Dynodwyr
Cyfenwau	SOD2, IPOB, MNSOD, MVCD6, IPO-B, Mn-SOD, superoxide dismutase 2, mitochondrial, superoxide dismutase 2, GClnc1
Dynodwyr allanol	OMIM: 147460 HomoloGene: 530 GeneCards: SOD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • superoxide dismutase activity • manganese ion binding • metal ion binding • identical protein binding • oxidoreductase activity Cydrannau o'r gell • mitocondria • extracellular exosome • mitochondrial matrix Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • response to superoxide • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • removal of superoxide radicals • acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure • regulation of blood pressure • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • protein homotetramerization • oxygen homeostasis • release of cytochrome c from mitochondria • superoxide metabolic process • negative regulation of cell population proliferation • positive regulation of cell migration • mitochondrion organization • cellular response to oxidative stress • interleukin-12-mediated signaling pathway • GO:0010260 heneiddio • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell apoptotic process • positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6648	n/a
Ensembl	ENSG00000112096	n/a
UniProt	P04179	n/a
RefSeq (mRNA)	NM_000636 NM_001024465 NM_001024466 NM_001322814 NM_001322815 NM_001322816 NM_001322817 NM_001322819 NM_001322820	n/a
RefSeq (protein)	NP_000627 NP_001019636 NP_001019637 NP_001309743 NP_001309744 NP_001309745 NP_001309746 NP_001309748 NP_001309749	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOD2 yw SOD2 a elwir hefyd yn Superoxide dismutase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOD2.

• IPOB
• IPO-B
• MNSOD
• MVCD6
• Mn-SOD

Llyfryddiaeth

• "ALA16VAL-MnSOD gene polymorphism and stroke: Association with dyslipidemia and glucose levels. ". Gene. 2017. PMID 28552711.
• "Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals. ". Acta Crystallogr F Struct Biol Commun. 2017. PMID 28368283.
• "Role for Functional SOD2 Polymorphism in Pulmonary Arterial Hypertension in a Chinese Population. ". Int J Environ Res Public Health. 2017. PMID 28272301.
• "Polymorphism variant of MnSOD A16V and risk of female infertility in northern Iran. ". Taiwan J Obstet Gynecol. 2016. PMID 28040123.
• "Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy.". Biomed Pharmacother. 2017. PMID 27923686.