SOCS3

SOCS3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BBU, 2HMH, 2JZ3, 4GL9
Dynodwyr
Cyfenwau	SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
Dynodwyr allanol	OMIM: 604176 HomoloGene: 2941 GeneCards: SOCS3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase inhibitor activity • GO:0001948, GO:0016582 protein binding • phosphotyrosine residue binding • 1-phosphatidylinositol-3-kinase regulator activity Cydrannau o'r gell • cytosol • cytoplasm • phosphatidylinositol 3-kinase complex • intracellular anatomical structure Prosesau biolegol • regulation of protein phosphorylation • trophoblast giant cell differentiation • GO:0007243 intracellular signal transduction • spongiotrophoblast differentiation • placenta blood vessel development • negative regulation of apoptotic process • GO:1903105 negative regulation of insulin receptor signaling pathway • regulation of interferon-gamma-mediated signaling pathway • branching involved in labyrinthine layer morphogenesis • protein ubiquitination • positive regulation of cell differentiation • regulation of cell differentiation • regulation of growth • negative regulation of signal transduction • negative regulation of inflammatory response • negative regulation of protein kinase activity • negative regulation of receptor signaling pathway via JAK-STAT • negative regulation of tyrosine phosphorylation of STAT protein • post-translational protein modification • cellular response to leukemia inhibitory factor • positive regulation of tyrosine phosphorylation of STAT protein • receptor signaling pathway via JAK-STAT • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase activity • phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9021	n/a
Ensembl	ENSG00000184557	n/a
UniProt	O14543 Q6FI39	n/a
RefSeq (mRNA)	NM_003955 NM_001378932 NM_001378933	n/a
RefSeq (protein)	NP_003946 NP_001365861 NP_001365862 NP_003946.3	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOCS3 yw SOCS3 a elwir hefyd yn Suppressor of cytokine signaling 3 a SOCS3 protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOCS3.

• CIS3
• SSI3
• ATOD4
• Cish3
• SSI-3
• SOCS-3

Llyfryddiaeth

• "SOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B. ". Oncotarget. 2017. PMID 28179578.
• "[Methylation Status of the SOCS3 Gene Promoter in H2228 Cells and 
EML4-ALK-positive Lung Cancer Tissues]. ". Zhongguo Fei Ai Za Zhi. 2016. PMID 27666544.
• "Prognostic significance of SOCS3 and its biological function in colorectal cancer. ". Gene. 2017. PMID 28603075.
• "[Role of negative regulators of SOCS1, SOCS3, and SOCS5 gene transcription in the negative cell signaling regulation system in asthma]. ". Ter Arkh. 2017. PMID 28378729.
• "Enhanced SOCS3 in osteoarthiritis may limit both proliferation and inflammation.". Biotech Histochem. 2017. PMID 28296552.