SNTA1

SNTA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QAV, 1Z86, 1Z87, 2ADZ, 2PDZ, 4HOP
Dynodwyr
Cyfenwau	SNTA1, LQT12, SNT1, TACIP1, dJ1187J4.5, Syntrophin, alpha 1, syntrophin alpha 1
Dynodwyr allanol	OMIM: 601017 HomoloGene: 2331 GeneCards: SNTA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sodium channel regulator activity • nitric-oxide synthase binding • transmembrane transporter binding • ATPase binding • structural molecule activity • calmodulin binding • GO:0001948, GO:0016582 protein binding • actin binding • PDZ domain binding Cydrannau o'r gell • cytoplasm • lateral plasma membrane • bilen • neuromuscular junction • Cellbilen • intracellular anatomical structure • cell junction • sarcolemma • syntrophin complex • Cytosgerbwd • GO:0009327 protein-containing complex • dystrophin-associated glycoprotein complex • synapse Prosesau biolegol • muscle contraction • negative regulation of peptidyl-cysteine S-nitrosylation • ventricular cardiac muscle cell action potential • regulation of heart rate • regulation of sodium ion transmembrane transport • regulation of ventricular cardiac muscle cell membrane repolarization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6640	n/a
Ensembl	ENSG00000101400	n/a
UniProt	Q13424	n/a
RefSeq (mRNA)	NM_003098	n/a
RefSeq (protein)	NP_003089	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SNTA1 yw SNTA1 a elwir hefyd yn Syntrophin alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SNTA1.

• SNT1
• LQT12
• TACIP1
• dJ1187J4.5

Llyfryddiaeth

• "The adaptor protein alpha-syntrophin is reduced in human non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma. ". Exp Mol Pathol. 2017. PMID 28941732.
• "Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. ". Br J Cancer. 2014. PMID 24434436.
• "α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. ". PLoS One. 2016. PMID 27028743.
• "Alpha-1-syntrophin protein is differentially expressed in human cancers. ". Biomarkers. 2011. PMID 21091386.
• "Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast.". FEBS Lett. 1996. PMID 8612778.