SNRPB

SNRPB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1D3B, 3CW1, 3PGW, 4PJO, 4WZJ, 3JCR
Dynodwyr
Cyfenwau	SNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
Dynodwyr allanol	OMIM: 182282 HomoloGene: 134543 GeneCards: SNRPB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • histone pre-mRNA DCP binding • U2 snRNA binding • GO:0001948, GO:0016582 protein binding • telomerase RNA binding • RNA binding • U1 snRNP binding • U2 snRNP binding Cydrannau o'r gell • cytoplasm • SMN-Sm protein complex • cytosol • catalytic step 2 spliceosome • U4/U6 x U5 tri-snRNP complex • histone pre-mRNA 3'end processing complex • U5 snRNP • U12-type spliceosomal complex • U2 snRNP • U1 snRNP • methylosome • U7 snRNP • small nuclear ribonucleoprotein complex • telomerase holoenzyme complex • spliceosomal complex • U4 snRNP • extracellular exosome • U2-type prespliceosome • cnewyllyn cell • nucleoplasm • U2-type precatalytic spliceosome • U2-type catalytic step 2 spliceosome Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • spliceosomal snRNP assembly • RNA splicing • histone mRNA metabolic process • protein methylation • import into nucleus • brain development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6628	n/a
Ensembl	ENSG00000125835	n/a
UniProt	P14678	n/a
RefSeq (mRNA)	NM_198216 NM_003091	n/a
RefSeq (protein)	NP_003082 NP_937859	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SNRPB yw SNRPB a elwir hefyd yn Small nuclear ribonucleoprotein polypeptides B and B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SNRPB.

• COD
• CCMS
• SNRPB1
• SmB/B'
• Sm-B/B'
• snRNP-B
• SmB/SmB'

Llyfryddiaeth

• "Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro-costo-mandibular syndrome. ". Nat Commun. 2014. PMID 25047197.
• "Spliceosomal UsnRNP biogenesis, structure and function. ". Curr Opin Cell Biol. 2001. PMID 11343899.
• "Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. ". Genome Biol. 2016. PMID 27287018.
• "Cerebro-costo-mandibular syndrome: Clinical, radiological, and genetic findings. ". Am J Med Genet A. 2016. PMID 26971886.
• "Mutations in SNRPB, encoding components of the core splicing machinery, cause cerebro-costo-mandibular syndrome.". Hum Mutat. 2015. PMID 25504470.