SMG7

SMG7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YA0
Dynodwyr
Cyfenwau	SMG7, C1orf16, EST1C, SGA56M, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor
Dynodwyr allanol	OMIM: 610964 HomoloGene: 32235 GeneCards: SMG7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein phosphatase 2A binding • GO:0001948, GO:0016582 protein binding • telomeric DNA binding • ribonuclease activity • ribonucleoprotein complex binding • telomerase RNA binding Cydrannau o'r gell • cytoplasm • intermediate filament cytoskeleton • cnewyllyn cell • telomerase holoenzyme complex • cytosol Prosesau biolegol • regulation of dephosphorylation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • mRNA export from nucleus • telomere maintenance via telomerase • regulation of RNA stability • RNA phosphodiester bond hydrolysis • regulation of telomere maintenance via telomerase Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9887	n/a
Ensembl	ENSG00000116698	n/a
UniProt	Q92540	n/a
RefSeq (mRNA)	NM_001174061 NM_014837 NM_173156 NM_201568 NM_201569 NM_001331007 NM_001350219 NM_001350220 NM_001350221 NM_001350222 NM_001375584 NM_001375585	n/a
RefSeq (protein)	NP_001167532 NP_001317936 NP_775179 NP_963862 NP_963863 NP_001337148 NP_001337149 NP_001337150 NP_001337151 NP_001362513 NP_001362514	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMG7 yw SMG7 a elwir hefyd yn Protein SMG7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMG7.

• EST1C
• SGA56M
• C1orf16

Llyfryddiaeth

• "Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. ". Ann Rheum Dis. 2016. PMID 26783109.
• "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. ". Mol Cell. 2004. PMID 15546618.
• "Frameshift Mutations of SMG7 Essential for Nonsense-Mediated mRNA Decay in Gastric and Colorectal Cancers. ". Pathol Oncol Res. 2017. PMID 27771886.
• "Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. ". RNA. 2017. PMID 28461625.
• "Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.". RNA. 2017. PMID 27864472.