SMG6

SMG6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DOK, 2HWW, 2HWX, 4UM2
Dynodwyr
Cyfenwau	SMG6, C17orf31, EST1A, SMG-6, hSMG5/7a, nonsense mediated mRNA decay factor, SMG6 nonsense mediated mRNA decay factor, hEST1A
Dynodwyr allanol	OMIM: 610963 HomoloGene: 23024 GeneCards: SMG6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • telomeric DNA binding • metal ion binding • DNA polymerase binding • GO:0001948, GO:0016582 protein binding • nuclease activity • endonuclease activity • hydrolase activity • telomerase RNA binding • endoribonuclease activity • RNA binding • ribonucleoprotein complex binding • ribonuclease activity Cydrannau o'r gell • cytoplasm • cytosol • exon-exon junction complex • Cromosom • telomere • telomerase catalytic core complex • nucleolus • telomerase holoenzyme complex • cnewyllyn cell Prosesau biolegol • nucleic acid phosphodiester bond hydrolysis • mRNA export from nucleus • negative regulation of telomere capping • regulation of dephosphorylation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • RNA phosphodiester bond hydrolysis, endonucleolytic • regulation of RNA stability • regulation of telomere maintenance • regulation of telomere maintenance via telomerase • regulation of telomerase activity • telomere maintenance via telomerase • RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23293	n/a
Ensembl	ENSG00000070366	n/a
UniProt	Q86US8	n/a
RefSeq (mRNA)	NM_001170957 NM_001256827 NM_001256828 NM_001282326 NM_017575	n/a
RefSeq (protein)	NP_001243756 NP_001243757 NP_001269255 NP_060045	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMG6 yw SMG6 a elwir hefyd yn Telomerase-binding protein EST1A a SMG6, nonsense mediated mRNA decay factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMG6.

• EST1A
• SMG-6
• C17orf31
• hSMG5/7a

Llyfryddiaeth

• "Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer. ". Genomics. 2000. PMID 11087658.
• "Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. ". RNA. 2017. PMID 28461625.
• "Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. ". Nucleic Acids Res. 2015. PMID 25429978.
• "Crystal structure of the PIN domain of human telomerase-associated protein EST1A. ". Proteins. 2007. PMID 17557331.
• "Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID 16820686.