SMARCA4

SMARCA4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GRC, 2H60, 3UVD, 5DKD, 5EA1
Dynodwyr
Cyfenwau	SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Dynodwyr allanol	OMIM: 603254 HomoloGene: 135927 GeneCards: SMARCA4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • nucleotide binding • GO:0001105 transcription coactivator activity • ATP-dependent activity, acting on DNA • GO:0001187 RNA polymerase I core promoter sequence-specific DNA binding • GO:0008026 helicase activity • GO:0001106 transcription corepressor activity • protein N-terminus binding • GO:0031493 histone binding • p53 binding • transcription factor binding • Tat protein binding • DNA polymerase binding • hydrolase activity, acting on acid anhydrides • ATPase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • lysine-acetylated histone binding • nucleosomal DNA binding • hydrolase activity • ATP binding • RNA binding • DNA binding Cydrannau o'r gell • nBAF complex • bilen • SWI/SNF complex • nucleoplasm • npBAF complex • nucleolus • cnewyllyn cell • extracellular space • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of glucose mediated signaling pathway • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I • negative regulation of androgen receptor signaling pathway • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • negative regulation of cell growth • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation by host of viral transcription • neural retina development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • beta-catenin-TCF complex assembly • nucleosome disassembly • GO:0045996 negative regulation of transcription, DNA-templated • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • interleukin-7-mediated signaling pathway • RNA polymerase I preinitiation complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6597	n/a
Ensembl	ENSG00000127616	n/a
UniProt	P51532 Q9HBD4	n/a
RefSeq (mRNA)	NM_001128844 NM_001128845 NM_001128846 NM_001128847 NM_001128848 NM_001128849 NM_003072	n/a
RefSeq (protein)	NP_001122316 NP_001122317 NP_001122318 NP_001122319 NP_001122320 NP_001122321 NP_003063 NP_001361386 NP_001122321.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMARCA4 yw SMARCA4 a elwir hefyd yn SMARCA4 isoform 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMARCA4.

• BRG1
• CSS4
• SNF2
• SWI2
• MRD16
• RTPS2
• BAF190
• SNF2L4
• SNF2LB
• hSNF2b
• BAF190A

Llyfryddiaeth

• "Brahma-related gene 1 induces apoptosis in a p53-dependent manner in human rheumatoid fibroblast-like synoviocyte MH7A. ". Medicine (Baltimore). 2016. PMID 28002318.
• "Increased Brahma-related Gene 1 Expression Predicts Distant Metastasis and Shorter Survival in Patients with Invasive Ductal Carcinoma of the Breast. ". Anticancer Res. 2016. PMID 27630343.
• "Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type. ". Gynecol Oncol. 2017. PMID 29102090.
• "BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasiveness. ". PLoS One. 2017. PMID 28700662.
• "i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene.". Biochimie. 2017. PMID 28619677.