SMARCA2

SMARCA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DAT, 5DKC, 4QY4
Dynodwyr
Cyfenwau	SMARCA2, BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, BIS
Dynodwyr allanol	OMIM: 600014 HomoloGene: 2308 GeneCards: SMARCA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001105 transcription coactivator activity • DNA binding • ATP-dependent activity, acting on DNA • GO:0008026 helicase activity • GO:0031493 histone binding • chromatin binding • hydrolase activity, acting on acid anhydrides • GO:0001948, GO:0016582 protein binding • hydrolase activity • ATP binding • ATPase activity Cydrannau o'r gell • nBAF complex • intracellular membrane-bounded organelle • nucleoplasm • npBAF complex • intermediate filament cytoskeleton • cnewyllyn cell • SWI/SNF complex Prosesau biolegol • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cell growth • spermatid development • GO:0045996 negative regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6595	n/a
Ensembl	ENSG00000080503	n/a
UniProt	P51531	n/a
RefSeq (mRNA)	NM_139045 NM_001289396 NM_001289397 NM_001289398 NM_001289399 NM_001289400 NM_003070	n/a
RefSeq (protein)	NP_001276325 NP_001276326 NP_001276327 NP_001276328 NP_001276329 NP_003061 NP_620614	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMARCA2 yw SMARCA2 a elwir hefyd yn Probable global transcription activator SNF2L2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9p24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMARCA2.

• BRM
• SNF2
• SWI2
• hBRM
• NCBRS
• Sth1p
• BAF190
• SNF2L2
• SNF2LA
• hSNF2a

Llyfryddiaeth

• "New SMARCA2 mutation in a patient with Nicolaides-Baraitser syndrome and myoclonic astatic epilepsy. ". Am J Med Genet A. 2017. PMID 27665729.
• "BRM polymorphisms, pancreatic cancer risk and survival. ". Int J Cancer. 2016. PMID 27487558.
• "Two BRM promoter polymorphisms predict poor survival in patients with hepatocellular carcinoma. ". Mol Carcinog. 2018. PMID 28892201.
• "BRM promoter insertion polymorphisms increase the risk of cancer: A meta-analysis. ". Gene. 2017. PMID 28571677.
• "BRM/SMARCA2-negative clear cell renal cell carcinoma is associated with a high percentage of BRM somatic mutations, deletions and promoter methylation.". Histopathology. 2017. PMID 28070921.