SLN

SLN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JDM
Dynodwyr
Cyfenwau	SLN, sarcolipin
Dynodwyr allanol	OMIM: 602203 GeneCards: SLN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATPase binding • GO:0048551 enzyme inhibitor activity • GO:0010576 enzyme regulator activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • endoplasmic reticulum membrane • bilen • Reticwlwm endoplasmig • sarcoplasmic reticulum membrane • sarcoplasmic reticulum Prosesau biolegol • positive regulation of protein depolymerization • negative regulation of protein-containing complex disassembly • negative regulation of calcium ion binding • regulation of calcium ion transport • GO:0048553 negative regulation of catalytic activity • negative regulation of calcium ion transmembrane transporter activity • calcium ion transport • negative regulation of calcium ion import • sarcoplasmic reticulum calcium ion transport • regulation of relaxation of muscle • regulation of ATPase-coupled calcium transmembrane transporter activity • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6588	n/a
Ensembl	ENSG00000170290	n/a
UniProt	O00631	n/a
RefSeq (mRNA)	NM_003063	n/a
RefSeq (protein)	NP_003054	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLN yw SLN a elwir hefyd yn Sarcolipin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.3.

Llyfryddiaeth

• "Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail. ". J Biol Chem. 2013. PMID 23362265.
• "Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation. ". Biochem Biophys Res Commun. 2011. PMID 21640081.
• "Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations. ". Proteins. 2017. PMID 28241400.
• "Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel. ". Arch Biochem Biophys. 2016. PMID 27378083.
• "Molecular dynamics of water and monovalent-ions transportation mechanisms of pentameric sarcolipin.". Proteins. 2016. PMID 26522287.