SLK

SLK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2J51, 2JFL, 2JFM, 2UV2, 4USF
Dynodwyr
Cyfenwau	SLK, LOSK, STK2, bA16H23.1, se20-9, STE20 like kinase
Dynodwyr allanol	OMIM: 616563 HomoloGene: 22515 GeneCards: SLK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • cadherin binding Cydrannau o'r gell • extracellular exosome • cell leading edge • perinuclear region of cytoplasm • cytoplasm Prosesau biolegol • phosphorylation • protein phosphorylation • cytoplasmic microtubule organization • regulation of focal adhesion assembly • protein autophosphorylation • GO:0097285 apoptotic process • regulation of cell migration • regulation of apoptotic process • regulation of mitotic cell cycle • GO:0072468 signal transduction • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9748	n/a
Ensembl	ENSG00000065613	n/a
UniProt	Q9H2G2	n/a
RefSeq (mRNA)	NM_001304743 NM_014720	n/a
RefSeq (protein)	NP_001291672 NP_055535	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLK yw SLK a elwir hefyd yn STE20 like kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q24.33-q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLK.

• LOSK
• STK2
• se20-9
• bA16H23.1

Llyfryddiaeth

• "SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation. ". J Cell Biol. 2014. PMID 24958772.
• "Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation. ". J Biol Chem. 2012. PMID 22203681.
• "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. ". Biochim Biophys Acta. 2000. PMID 10699464.
• "A yeast gene that is essential for release from glucose repression encodes a protein kinase. ". Science. 1986. PMID 3526554.
• "SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization.". Cytoskeleton (Hoboken). 2016. PMID 26818812.