SLIT2

SLIT2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2V70, 2V9S, 2V9T, 2WFH
Dynodwyr
Cyfenwau	SLIT2, SLIL3, Slit-2, slit guidance ligand 2
Dynodwyr allanol	OMIM: 603746 HomoloGene: 3516 GeneCards: SLIT2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • heparin binding • protein homodimerization activity • GTPase inhibitor activity • laminin-1 binding • GO:0001948, GO:0016582 protein binding • identical protein binding • Roundabout binding • proteoglycan binding Cydrannau o'r gell • cytoplasm • bilen • extracellular region • cell surface • extracellular exosome • Cellbilen • extracellular space Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • negative regulation of chemokine-mediated signaling pathway • negative regulation of neutrophil chemotaxis • negative regulation of cellular response to growth factor stimulus • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • cell differentiation • ureteric bud development • negative chemotaxis • negative regulation of actin filament polymerization • negative regulation of small GTPase mediated signal transduction • negative regulation of retinal ganglion cell axon guidance • negative regulation of mononuclear cell migration • corticospinal neuron axon guidance through spinal cord • negative regulation of smooth muscle cell migration • Roundabout signaling pathway • positive regulation of axonogenesis • nervous system development • cell migration involved in sprouting angiogenesis • negative regulation of endothelial cell migration • axon guidance • multicellular organism development • chemotaxis • negative regulation of smooth muscle cell chemotaxis • cellular response to hormone stimulus • negative regulation of cell migration • negative regulation of monocyte chemotaxis • negative regulation of cell growth • response to cortisol • apoptotic process involved in luteolysis • positive regulation of apoptotic process • induction of negative chemotaxis • cellular response to heparin • motor neuron axon guidance • branching morphogenesis of an epithelial tube • negative regulation of leukocyte chemotaxis • chemorepulsion involved in postnatal olfactory bulb interneuron migration • axon extension involved in axon guidance • negative regulation of lamellipodium assembly • negative regulation of vascular permeability • retinal ganglion cell axon guidance • GO:0034259 negative regulation of GTPase activity • aortic valve morphogenesis • pulmonary valve morphogenesis • ventricular septum morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9353	n/a
Ensembl	ENSG00000145147	n/a
UniProt	O94813	n/a
RefSeq (mRNA)	NM_001289135 NM_001289136 NM_004787	n/a
RefSeq (protein)	NP_001276064 NP_001276065 NP_004778	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLIT2 yw SLIT2 a elwir hefyd yn Slit homolog 2 protein a Slit guidance ligand 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLIT2.

• SLIL3
• Slit-2

Llyfryddiaeth

• "Slit2 exerts anti-inflammatory actions in human placenta and is decreased with maternal obesity. ". Am J Reprod Immunol. 2015. PMID 25329354.
• "Slit2 is decreased after spontaneous labour in myometrium and regulates pro-labour mediators. ". J Reprod Immunol. 2014. PMID 25130654.
• "The differential roles of Slit2-exon 15 splicing variants in angiogenesis and HUVEC permeability. ". Angiogenesis. 2015. PMID 26021305.
• "Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling. ". Cell Death Dis. 2015. PMID 25590802.
• "Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.". Proc Natl Acad Sci U S A. 2014. PMID 25489114.