SLAMF1

SLAMF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M27, 1KA7, 1I3Z, 1D4T, 1D4W, 1KA6
Dynodwyr
Cyfenwau	SLAMF1, CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1
Dynodwyr allanol	OMIM: 603492 HomoloGene: 48162 GeneCards: SLAMF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0003823, GO:0051635 antigen binding • virus receptor activity • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • identical protein binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • extracellular region • cell surface • phagocytic vesicle • extracellular exosome • external side of plasma membrane Prosesau biolegol • adaptive immune response • immune system process • natural killer cell proliferation • T-helper 1 cell cytokine production • negative regulation of interleukin-6 production • positive regulation of JNK cascade • cell adhesion • negative regulation of CD40 signaling pathway • negative regulation of T cell cytokine production • myeloid dendritic cell activation involved in immune response • regulation of vesicle fusion • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • ffagocytosis • lymphocyte activation • viral entry into host cell • negative regulation of tumor necrosis factor production • innate immune response • GO:0048552 regulation of catalytic activity • GO:0022415 viral process • positive regulation of activated T cell proliferation • negative regulation of interleukin-12 production • natural killer cell differentiation • GO:0072468 signal transduction • leukocyte chemotaxis involved in inflammatory response • positive regulation of macrophage chemotaxis • positive regulation of dendritic cell chemotaxis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6504	n/a
Ensembl	ENSG00000117090	n/a
UniProt	Q13291	n/a
RefSeq (mRNA)	NM_003037 NM_001330754	n/a
RefSeq (protein)	NP_001317683 NP_003028	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLAMF1 yw SLAMF1 a elwir hefyd yn Signaling lymphocytic activation molecule family member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLAMF1.

• SLAM
• CD150
• CDw150

Llyfryddiaeth

• "Analysis of expression and function of the co-stimulatory receptor SLAMF1 in immune cells from patients with systemic lupus erythematosus (SLE). ". Lupus. 2015. PMID 25920347.
• "Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150. ". Biochemistry (Mosc). 2014. PMID 25716736.
• "The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis. ". J Virol. 2017. PMID 28100610.
• "Differential expression of CD150/SLAMF1 in normal and malignant B cells on the different stages of maturation. ". Exp Oncol. 2016. PMID 27356578.
• "SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response.". J Clin Invest. 2016. PMID 26619119.