SKP2

SKP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST
Dynodwyr
Cyfenwau	SKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2
Dynodwyr allanol	OMIM: 601436 HomoloGene: 55942 GeneCards: SKP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • GO:0050372 ubiquitin-protein transferase activity Cydrannau o'r gell • nucleoplasm • nucleolus • SCF ubiquitin ligase complex • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • regulation of apoptotic process • cellular response to cell-matrix adhesion • positive regulation of intracellular estrogen receptor signaling pathway • ubiquitin-dependent protein catabolic process • regulation of cell cycle • G2/M transition of mitotic cell cycle • protein ubiquitination • positive regulation of protein polyubiquitination • cell population proliferation • positive regulation of smooth muscle cell proliferation • protein polyubiquitination • protein deubiquitination • post-translational protein modification • G1/S transition of mitotic cell cycle • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • innate immune response • defense response to virus • protein K48-linked ubiquitination • immune system process • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6502	n/a
Ensembl	ENSG00000145604	n/a
UniProt	Q13309	n/a
RefSeq (mRNA)	NM_001243120 NM_005983 NM_032637	n/a
RefSeq (protein)	NP_001230049 NP_005974 NP_116026	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SKP2 yw SKP2 a elwir hefyd yn S-phase kinase associated protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SKP2.

• p45
• FBL1
• FLB1
• FBXL1

Llyfryddiaeth

• "S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation. ". Genet Mol Res. 2015. PMID 26345857.
• "Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells. ". Oncotarget. 2015. PMID 26046466.
• "Overexpression of SKP2 Inhibits the Radiation-Induced Bystander Effects of Esophageal Carcinoma. ". Int J Environ Res Public Health. 2017. PMID 28178195.
• "Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma. ". Pathol Oncol Res. 2016. PMID 26874697.
• "[Over-expression of human S-phase kinase-associated protein 2 (Skp2) promotes proliferation of MCF-7 breast cancer cells and increases the number of S phase cells].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015. PMID 26429528.