SKI

SKI
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MR1, 1SBX
Dynodwyr
Cyfenwau	SKI, SKI proto-oncogene, SGS, SKV
Dynodwyr allanol	OMIM: 164780 HomoloGene: 31124 GeneCards: SKI
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • protein domain specific binding • histone deacetylase inhibitor activity • zinc ion binding • GO:0001948, GO:0016582 protein binding • SMAD binding • protein kinase binding • ubiquitin protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • PML body • centrosome • nuclear body • cnewyllyn cell • nucleoplasm • transcription regulator complex • cytoplasm • transcription repressor complex • GO:0009327 protein-containing complex Prosesau biolegol • roof of mouth development • myotube differentiation • SMAD protein signal transduction • somatic stem cell population maintenance • nose morphogenesis • cell motility • bone morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of osteoblast differentiation • myelination in peripheral nervous system • protein homotrimerization • negative regulation of BMP signaling pathway • positive regulation of Wnt signaling pathway • negative regulation of activin receptor signaling pathway • neural tube closure • lens morphogenesis in camera-type eye • embryonic limb morphogenesis • skeletal muscle fiber development • retina development in camera-type eye • camera-type eye development • positive regulation of DNA binding • olfactory bulb development • cell population proliferation • anterior/posterior axis specification • negative regulation of fibroblast proliferation • face morphogenesis • camera-type eye morphogenesis • negative regulation of Schwann cell proliferation • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • negative regulation of histone deacetylation • neuron development • transforming growth factor beta receptor signaling pathway • negative regulation of cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6497	n/a
Ensembl	ENSG00000157933	n/a
UniProt	P12755	n/a
RefSeq (mRNA)	NM_003036	n/a
RefSeq (protein)	NP_003027	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SKI yw SKI a elwir hefyd yn SKI proto-oncogene (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.33-p36.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SKI.

• SGS
• SKV

Llyfryddiaeth

• "Ski regulates Smads and TAZ signaling to suppress lung cancer progression. ". Mol Carcinog. 2017. PMID 28398634.
• "The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen-Goldberg syndrome. ". Eur J Hum Genet. 2015. PMID 24736733.
• "c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion. ". Mol Oncol. 2013. PMID 24011664.
• "576 kb deletion in 1p36.33-p36.32 containing SKI is associated with limb malformation, congenital heart disease and epilepsy. ". Gene. 2013. PMID 23892090.
• "Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer.". Virology. 2013. PMID 23809940.