SKAP1

SKAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1U5D
Dynodwyr
Cyfenwau	SKAP1, HEL-S-81p, SCAP1, SKAP55, src kinase associated phosphoprotein 1
Dynodwyr allanol	OMIM: 604969 HomoloGene: 2764 GeneCards: SKAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • SH2 domain binding • GO:0001948, GO:0016582 protein binding • protein phosphatase binding • protein kinase binding • GO:0032403 protein-containing complex binding • protein homodimerization activity • microtubule plus-end binding Cydrannau o'r gell • cytoplasm • bilen • cell-cell junction • Cellbilen • T cell receptor complex • cnewyllyn cell • cytosol • ruffle • immunological synapse • microtubule plus-end • plasma membrane raft Prosesau biolegol • adaptive immune response • immune system process • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein localization to plasma membrane • T cell receptor signaling pathway • positive regulation of cell adhesion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of signal transduction • microtubule cytoskeleton organization • positive regulation of cell-matrix adhesion • positive regulation of adaptive immune response • cell migration • positive regulation of integrin activation • positive regulation of cell-cell adhesion mediated by integrin • positive regulation of heterotypic cell-cell adhesion • cellular response to epidermal growth factor stimulus • positive regulation of leukocyte cell-cell adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8631	n/a
Ensembl	ENSG00000141293	n/a
UniProt	Q86WV1	n/a
RefSeq (mRNA)	NM_001075099 NM_003726	n/a
RefSeq (protein)	NP_001068567 NP_003717	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SKAP1 yw SKAP1 a elwir hefyd yn Src kinase-associated phosphoprotein 1 a Src kinase associated phosphoprotein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SKAP1.

• SCAP1
• SKAP55
• HEL-S-81p

Llyfryddiaeth

• "Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling. ". Immunol Lett. 1997. PMID 9232446.
• "D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. ". Mol Cell Biol. 2017. PMID 28052935.
• "The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms. ". J Cell Biol. 2013. PMID 24368808.
• "SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. ". Nat Immunol. 2003. PMID 12652296.
• "Integration of T cell receptor-dependent signaling pathways by adapter proteins.". Annu Rev Immunol. 1999. PMID 10358754.