SIAH1

SIAH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2A25, 4C9Z, 4CA1, 4I7B, 4I7C, 4I7D, 4X3G
Dynodwyr
Cyfenwau	SIAH1, SIAH1A, siah E3 ubiquitin protein ligase 1, BURHAS
Dynodwyr allanol	OMIM: 602212 HomoloGene: 20654 GeneCards: SIAH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • identical protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0001948, GO:0016582 protein binding • zinc ion binding • transferase activity • GO:0050372 ubiquitin-protein transferase activity • protein C-terminus binding • ubiquitin conjugating enzyme binding Cydrannau o'r gell • beta-catenin destruction complex • cytoplasm • cnewyllyn cell • early endosome • cytosol • Cellbilen Prosesau biolegol • cell cycle • spermatogenesis • axon guidance • multicellular organism development • anatomical structure morphogenesis • positive regulation of intrinsic apoptotic signaling pathway • GO:0097285 apoptotic process • GO:0044257 protein catabolic process • positive regulation of apoptotic process • nervous system development • protein ubiquitination • cell differentiation • protein polyubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • protein destabilization • neuron apoptotic process • ubiquitin-dependent protein catabolic process • negative regulation of netrin-activated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6477	n/a
Ensembl	ENSG00000196470	n/a
UniProt	Q8IUQ4	n/a
RefSeq (mRNA)	NM_001006610 NM_003031 NM_001006611	n/a
RefSeq (protein)	NP_001006611 NP_003022	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIAH1 yw SIAH1 a elwir hefyd yn Siah E3 ubiquitin protein ligase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIAH1.

• SIAH1A

Llyfryddiaeth

• "Siah1 proteins enhance radiosensitivity of human breast cancer cells. ". BMC Cancer. 2010. PMID 20682032.
• "SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells. ". Cancer Sci. 2010. PMID 19775288.
• "Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. ". PLoS One. 2016. PMID 27249023.
• "Silencing of SIAH1 in SH-SY5Y affects α-synuclein degradation pathway. ". Int J Clin Exp Pathol. 2015. PMID 26722480.
• "Two high-resolution structures of the human E3 ubiquitin ligase Siah1.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID 24316825.