SH3GL2

SH3GL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X03, 1X04, 2D4C, 2DBM
Dynodwyr
Cyfenwau	SH3GL2, CNSA2, EEN-B1, SH3D2A, SH3P4, SH3 domain containing GRB2 like 2, endophilin A1
Dynodwyr allanol	OMIM: 604465 HomoloGene: 20652 GeneCards: SH3GL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • lipid binding • identical protein binding • protein homodimerization activity • protein C-terminus binding • protein kinase binding Cydrannau o'r gell • cytoplasm • clathrin-coated endocytic vesicle membrane • bilen • Golgi membrane • Cellbilen • synapse • early endosome • endosome • cytosol • neuronal cell body • perinuclear region of cytoplasm • basal dendrite • presynapse • synaptic vesicle membrane • photoreceptor ribbon synapse • Schaffer collateral - CA1 synapse • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse • presynaptic cytosol Prosesau biolegol • negative regulation of epidermal growth factor receptor signaling pathway • endocytosis • antigen processing and presentation of exogenous peptide antigen via MHC class II • central nervous system development • synaptic vesicle endocytosis • regulation of receptor internalization • GO:0072468 signal transduction • membrane organization • synaptic vesicle uncoating • neuron projection development • dendrite extension • cellular response to brain-derived neurotrophic factor stimulus • lipid tube assembly • membrane tubulation • membrane bending • vesicle scission • positive regulation of membrane tubulation • regulation of clathrin-dependent endocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6456	n/a
Ensembl	ENSG00000107295	n/a
UniProt	Q99962	n/a
RefSeq (mRNA)	NM_003026	n/a
RefSeq (protein)	NP_003017	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SH3GL2 yw SH3GL2 a elwir hefyd yn SH3 domain containing GRB2 like 2, endophilin A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9p22.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SH3GL2.

• CNSA2
• SH3P4
• EEN-B1
• SH3D2A

Llyfryddiaeth

• "Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior. ". Neoplasia. 2013. PMID 23814487.
• "MicroRNA-330 is an oncogenic factor in glioblastoma cells by regulating SH3GL2 gene. ". PLoS One. 2012. PMID 23029364.
• "Aberrant promoter methylation of SH3GL2 gene in vulvar squamous cell carcinoma correlates with clinicopathological characteristics and HPV infection status. ". Int J Clin Exp Pathol. 2015. PMID 26823912.
• "SNP rs1049430 in the 3'-UTR of SH3GL2 regulates its expression: Clinical and prognostic implications in head and neck squamous cell carcinoma. ". Biochim Biophys Acta. 2015. PMID 25728707.
• "Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway.". Brain Res. 2015. PMID 25721793.